HEREDIA MOYA, JORGE HUMBERTO
Preferred name
HEREDIA MOYA, JORGE HUMBERTO
Main Affiliation
CENBIO - Centro de Investigación Biomédica
Web Site
ORCID
0000-0001-7620-9140
Scopus Author ID
8680066700
36 results
Now showing 1 - 10 of 36
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Item type:Publication, Phytosynthesis of Silver Nanoparticles Using Mansoa alliacea (Lam.) A.H. Gentry (Bignoniaceae) Leaf Extract: Characterization and Their Biological Activities(MDPI AG, 2024-09-25); ; ; Cristina Rodríguez-PólitBackground. Mansoa alliacea is a native plant renowned for its medicinal properties in traditional healing in the Amazon Region. This plant is rich in polyphenols, flavonoids, anthocyanins, phenolic acids, tannins, ketones, triterpenes, as well as other bioactive compounds. Objectives. This study aims to develop an innovative, eco-friendly method for synthesizing silver nanoparticles using an aqueous extract of M. alliacea (Ma-AgNPs), enhancing the biological activities of AgNPs by leveraging the therapeutic potential of the plant’s bioactive compounds. Methods. Silver nanoparticles were synthesized using the aqueous extract of M. alliacea. The biological activities of Ma-AgNPs were assessed, including antibacterial, anti-inflammatory, antioxidant, antitumor, and anti-biofilm effects, along with evaluating their hemolytic activity. Results. Quantitative analysis revealed that Ma-AgNPs exhibit potent antibacterial activity against multidrug and non-multidrug-resistant bacteria, with MIC values ranging from 1.3 to 10.0 µg/mL. The Ma-AgNPs significantly reduced NO production by 86.9% at 4 µg/mL, indicating strong anti-inflammatory effects. They demonstrated robust antioxidant activity with an IC50 of 5.54 ± 1.48 µg/mL and minimal hemolytic activity, with no hemolysis observed up to 20 µg/mL and only 4.5% at 40 µg/mL. Their antitumor properties were notable, with IC50 values between 2.9 and 5.4 µg/mL across various cell lines, and they achieved over 50% biofilm inhibition at concentrations of 30–40 µg/mL. Conclusions. These findings underscore the potential of Ma-AgNPs for biomedical applications, particularly in developing new antimicrobial agents and bioactive coatings with reduced toxicity. This research highlights a sustainable approach that not only preserves but also amplifies the inherent biological activities of plant extracts, paving the way for innovative therapeutic solutions.Scopus© Citations 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Functional and Antimicrobial Evaluation of Artocarpus Heterophyllus (Jackfruit) Fruit and Leaves at Different Ripening Stages(Springer Nature Switzerland, 2025-04-23); Gabriela MéndezJackfruit is an exotic fruit that has aroused interest due to its size and nutritional potential. Therefore, this study aimed to quantify the physicochemical properties of pulp, seeds, peel, and leaves of Artocarpus heterophyllus. The fruit was collected at three stages of maturity (M1, immature; M2, physiological maturity; and M3, commercial maturity) and left at two sets of vegetative development (NL, new; OL, old). Weight, size, soluble solids, pH, titratable acidity, moisture, ash, phenolics, carotenoids, organic acids, saponins, antioxidant and antimicrobial activity were determined. Bioactive compounds and antioxidant activity were used in a solution obtained by microextraction, and quantification was performed using spectrophotometric methods in microplates. The results showed a high concentration of total phenolics in the leaves (50.78 mg GAE 100 g−1 DW in M1) and carotenoid in the pulp of M3 (316.8 mg β-carotene 100 g−1 DW). At the same time, malic acid was mainly found in the pulp (3,077.7 mg 100 g−1 DW in M1), saponins in the leaves (11.3% in NL), and antioxidant activity in the pulp and seeds of M1 (3.8 and 4.2 mmol TE g-1 DW, respectively) and M2 (4.0 and 4.3 mmol TE g−1 DW, respectively). In turn, leaves showed inhibition of Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, and Staphylococcus aureus. These results highlight the diversity and relevance of chemical constituents in different parts of jackfruit and their potential benefits for human health, including the leaves, seeds, and shells. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phenylthiadiazole-Based Schiff Base Fluorescent Chemosensor for the Detection of Al3+ and Zn2+ IonsAluminum (Al) and zinc (Zn) are two of the most widely used metals in industry, and their excessive accumulation in the body has been linked to serious diseases like Alzheimer’s, Parkinson’s, and cancer. This highlights the need for effective ways to detect and measure them. In this study, we synthesized the fluorescent chemosensor 1, which contains a Schiff base and a 1,3,4-thiadiazole ring in its structure, and evaluated its fluorescent response in the presence of various metal ions. The chemosensor enabled the selective quantification of Al3+ and Zn2+ ions through excitations at different wavelengths, yielding differentiated fluorescent emissions. For Al3+, excitation at 370 nm generated a strong emission at 480 nm, whereas for Zn2+, excitation at 320 nm led to a new small broad emission at 560 nm. We established detection limits of 2.22 × 10−6 M for Al3+ and 1.62 × 10−5 M for Zn2+; their binding stoichiometry was found to be 1:1 for Al3+ and 2:1 for Zn2+, based on Job’s plot analysis. These results show that chemosensor 1 is a promising tool for detecting Al3+ and Zn2+.Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Iron Oxide Nanoparticles: Green Synthesis and Their Antimicrobial Activity(MDPI AG, 2023-11-08); ; Carlos Barba-Ostria<jats:p>The rise of antimicrobial resistance caused by inappropriate use of these agents in various settings has become a global health threat. Nanotechnology offers the potential for the synthesis of nanoparticles (NPs) with antimicrobial activity, such as iron oxide nanoparticles (IONPs). The use of IONPs is a promising way to overcome antimicrobial resistance or pathogenicity because of their ability to interact with several biological molecules and to inhibit microbial growth. In this review, we outline the pivotal findings over the past decade concerning methods for the green synthesis of IONPs using bacteria, fungi, plants, and organic waste. Subsequently, we delve into the primary challenges encountered in green synthesis utilizing diverse organisms and organic materials. Furthermore, we compile the most common methods employed for the characterization of these IONPs. To conclude, we highlight the applications of these IONPs as promising antibacterial, antifungal, antiparasitic, and antiviral agents.</jats:p>Scopus© Citations 147 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antimicrobial, Antioxidant, Antitumor, and Anti-Inflammatory Properties of Gleichenella pectinata, a Bioprospecting of Medicinal Ferns(MDPI AG, 2025-11-12); Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Functional and Antioxidant Evaluation of Two Ecotypes of Control and Grafted Tree Tomato (Solanum betaceum) at Different Altitudes(MDPI AG, 2023-09-20)Scopus© Citations 22 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Functional, Antioxidant, and Antimicrobial Profile of Medicinal Leaves from the Amazon(MDPI AG, 2025-08-05)Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Bioactive Compounds, Antioxidant, and Antimicrobial Activity of Seeds and Mucilage of Non-Traditional Cocoas(MDPI AG, 2025-02-28)Scopus© Citations 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Ethyl (1R*,10S*,12R*,15S*)-4-Hydroxy-2-oxo-15- (2-oxo-1-pyrrolidinyl)-9-oxatetracyclo[10.2.2.01,10.03,8]hexadeca-3,5,7,13-tetraene-13-carboxylate<jats:p>N-Vinylpirrolidinone reacts with (E)-ethyl 5-hydroxy-3-(4-oxo-4H-chromen-3-yl) acrylate (1) through a domino reaction similar to that reported reaction for ethyl vinyl ether. Inverse electron demand Diels–Alder (IEDDA)–elimination-IEDDA generates isomeric tetracycles 5 and 6. The assignment of the relative stereochemistry of the products was made by comparing the proton couplings with those obtained by reaction with ethyl vinyl ether.</jats:p>Scopus© Citations 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High Molecular Weight Chitosan from Shrimp Shells: Synthesis of Para-Substituted Schiff Bases with Selective Leishmanicidal Activity and Application in CO2/O2-Selective Films(MDPI AG, 2026-06-04)Scopus© Citations 1