HEREDIA MOYA, JORGE HUMBERTO

Preferred name

Main Affiliation

Facultad de Ciencias de la Salud Eugenio Espejo

CENBIO - Centro de Investigación Biomédica

Web Site

Google Scholar

ORCID

0000-0001-7620-9140

Scopus Author ID

8680066700

Now showing 1 - 10 of 34

Some of the metrics are blocked by your
consent settings
Lacmellea oblongata and Other Undervalued Amazonian Fruits as Functional, Antioxidant, and Antimicrobial Matrices
(MDPI AG, 2025-07-29)
Elena Coyago-Cruz
;
Gabriela Méndez
;
Ruth Escobar-Quiñonez
;
Marco Cerna
;
HEREDIA MOYA, JORGE HUMBERTO
The Amazon represents a key source of food biodiversity and is home to native fruits with high nutritional and functional potential, many of which remain largely unstudied. This research aimed to evaluate the presence of bioactive compounds, as well as the antioxidant and antimicrobial activity of Miconia crenata, Grias neuberthii, Lacmellea oblongata, Pourouma cecprofiilia, and Annona edulis. Physical and chemical parameters, mineral content (atomic absorption), vitamin C, organic acid, carotenoids, chlorophylls, and phenols (liquid chromatography), antioxidant activity (ABTS, DPPH), and antimicrobial activity (against Candida albicans, Candida tropicalis, Escherichia coli, Staphylococcus aureus, and Streptococcus mutans) were determined. High concentrations of calcium, syringic acid, and antioxidant activity were found in the fruits of Miconia crenata; malic and caffeic acids in Grias neuberthii; citric acid, naringenin, and antioxidant activity in Lactuca oblongata; potassium, chlorogenic acid, and ferulic acid in Pourouma cecropiifolia; and tartaric acid and gallic acid in Annona edulis. Additionally, low antimicrobial activity was observed in M. crenata against E. coli (2.7 mg/mL), G. neuberthii against S. aureus (10.3 mg/mL), and L. oblongata against S. mutans (10.4 mg/mL), C. albicans (20.8 mg/mL), and C. tropicalis (20.8 mg/mL). The results confirm that these Amazonian fruits are a relevant source of functional bioactive compounds, highlighting their potential for use in the food, pharmaceutical, and biotechnology sectors.
Scopus© Citations 5
Some of the metrics are blocked by your
consent settings
Diaza-1,3-butadienes as Useful Intermediate in Heterocycles Synthesis
(MDPI AG, 2022-10-09)
HEREDIA MOYA, JORGE HUMBERTO
;
Daniel A. Zurita
;
José Eduardo Cadena-Cruz
;
Christian D. Alcívar-León
Many heterocyclic compounds can be synthetized using diaza-1,3-butadienes (DADs) as key structural precursors. Isolated and in situ diaza-1,3-butadienes, produced from their respective precursors (typically imines and hydrazones) under a variety of conditions, can both react with a wide range of substrates in many kinds of reactions. Most of these reactions discussed here include nucleophilic additions, Michael-type reactions, cycloadditions, Diels–Alder, inverse electron demand Diels–Alder, and aza-Diels–Alder reactions. This review focuses on the reports during the last 10 years employing 1,2-diaza-, 1,3-diaza-, 2,3-diaza-, and 1,4-diaza-1,3-butadienes as intermediates to synthesize heterocycles such as indole, pyrazole, 1,2,3-triazole, imidazoline, pyrimidinone, pyrazoline, -lactam, and imidazolidine, among others. Fused heterocycles, such as quinazoline, isoquinoline, and dihydroquinoxaline derivatives, are also included in the review.</jats:p>
Scopus© Citations 14
Some of the metrics are blocked by your
consent settings
Phytosynthesis of Silver Nanoparticles Using Mansoa alliacea (Lam.) A.H. Gentry (Bignoniaceae) Leaf Extract: Characterization and Their Biological Activities
(MDPI AG, 2024-09-25)
ZUÑIGA MIRANDA, JOHANA JANINA
;
Saskya E. Carrera-Pacheco
;
GONZALEZ PASTOR, REBECA EUGENIA
;
MAYORGA RAMOS, ARIANNA CAROLINA
;
Cristina Rodríguez-Pólit
Background. Mansoa alliacea is a native plant renowned for its medicinal properties in traditional healing in the Amazon Region. This plant is rich in polyphenols, flavonoids, anthocyanins, phenolic acids, tannins, ketones, triterpenes, as well as other bioactive compounds. Objectives. This study aims to develop an innovative, eco-friendly method for synthesizing silver nanoparticles using an aqueous extract of M. alliacea (Ma-AgNPs), enhancing the biological activities of AgNPs by leveraging the therapeutic potential of the plant’s bioactive compounds. Methods. Silver nanoparticles were synthesized using the aqueous extract of M. alliacea. The biological activities of Ma-AgNPs were assessed, including antibacterial, anti-inflammatory, antioxidant, antitumor, and anti-biofilm effects, along with evaluating their hemolytic activity. Results. Quantitative analysis revealed that Ma-AgNPs exhibit potent antibacterial activity against multidrug and non-multidrug-resistant bacteria, with MIC values ranging from 1.3 to 10.0 µg/mL. The Ma-AgNPs significantly reduced NO production by 86.9% at 4 µg/mL, indicating strong anti-inflammatory effects. They demonstrated robust antioxidant activity with an IC50 of 5.54 ± 1.48 µg/mL and minimal hemolytic activity, with no hemolysis observed up to 20 µg/mL and only 4.5% at 40 µg/mL. Their antitumor properties were notable, with IC50 values between 2.9 and 5.4 µg/mL across various cell lines, and they achieved over 50% biofilm inhibition at concentrations of 30–40 µg/mL. Conclusions. These findings underscore the potential of Ma-AgNPs for biomedical applications, particularly in developing new antimicrobial agents and bioactive coatings with reduced toxicity. This research highlights a sustainable approach that not only preserves but also amplifies the inherent biological activities of plant extracts, paving the way for innovative therapeutic solutions.
Scopus© Citations 13
Some of the metrics are blocked by your
consent settings
Ethyl (1R*,10S*,12R*,15S*)-4-Hydroxy-2-oxo-15- (2-oxo-1-pyrrolidinyl)-9-oxatetracyclo[10.2.2.01,10.03,8]hexadeca-3,5,7,13-tetraene-13-carboxylate
(MDPI AG, 2017-01-18)
HEREDIA MOYA, JORGE HUMBERTO
;
Ramiro Araya-Maturana
<jats:p>N-Vinylpirrolidinone reacts with (E)-ethyl 5-hydroxy-3-(4-oxo-4H-chromen-3-yl) acrylate (1) through a domino reaction similar to that reported reaction for ethyl vinyl ether. Inverse electron demand Diels–Alder (IEDDA)–elimination-IEDDA generates isomeric tetracycles 5 and 6. The assignment of the relative stereochemistry of the products was made by comparing the proton couplings with those obtained by reaction with ethyl vinyl ether.</jats:p>
Some of the metrics are blocked by your
consent settings
Functional, Antioxidant, Antibacterial, and Antifungal Activity of Edible Flowers
(MDPI AG, 2024-10-25)
Elena Coyago-Cruz
;
Alejandro Alarcón
;
Aida Guachamin
;
Gabriela Méndez
;
Edison Osorio
Edible flowers have been used since ancient times, but their potential for improving human health has not been explored. This study aimed to evaluate the profile of bioactive compounds (organic acids, phenolics, and carotenoids) and the antioxidant and antimicrobial activity of nine flower varieties with high concentrations of carotenoids or total phenolic compounds. Ninety-three edible flowers were analysed for physicochemical characteristics, total phenolic and carotenoid concentrations, and antioxidant activity (ABTS). Bioactive profiles were determined by rapid resolution liquid chromatography (RRLC), and antimicrobial activity was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus mutans, and Candida albicans and Candida tropicalis. Chrysanthemum x hybrid orange, Helianthus annuus yellow, Tagetes patula orange, Canna indica red, and Hibiscus rosa-sinensis (orange1 and yellow) showed significant concentrations of total carotenoids. In contrast, Pelargonium hortorum orange2, Hibiscus rosa-sinensis red1, and Rosa x hybrid variety medium yellow showed high levels of total phenolics. The predominant compounds in these species were citric acid (991.4 mg/g DW in Hibiscus rosa-sinensis red1), 4-hydroxybenzoic acid (936.2 mg/100 g DW in P. hortorum orange2), kaempferol (971. 9 mg/100 g DW in T. patula orange), quercetin glucoside (958.8 in C. x hybrid), quercetin (919.3 mg/100 g DW in T. patula), α-carotene, and β-carotene in T. patula orange (989.5 and 601.2 mg/100 g DW, respectively). Regarding antimicrobial activity, T. patula orange and P. hortorum orange2 inhibited bacterial growth, while C. x hybrid orange and P. hortorum orange2 inhibited Candida albicans, and the latter inhibited Candida tropicalis. These results indicate the potential of edible flowers as a natural source of bioactive compounds and as a tool in the fight against antimicrobial resistance.
Scopus© Citations 20
Some of the metrics are blocked by your
consent settings
Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents
(Springer Science and Business Media LLC, 2025-01-31)
ZUÑIGA MIRANDA, JOHANA JANINA
;
GONZALEZ PASTOR, REBECA EUGENIA
;
Saskya E. Carrera Pacheco
;
Cristina Rodríguez-Pólit
;
Carlos Barba-Ostria
Schiff bases are organic compounds recognized for their biological activities, including antiviral, antibacterial, antifungal, and anticancer properties, making them promising candidates in medicinal chemistry. In this studio, a series of Schiff bases derived from 4-aminoantipyrine and substituted cinnamaldehydes were evaluated in vitro against liver (HepG2) and thyroid (THJ29T) cancer cells, Gram-positive and Gram-negative multidrug-resistant bacteria, and biofilm-forming pathogens. Six compounds demonstrated anticancer activity, though some exhibited toxicity to non-tumor cells. Compounds showed notable anticancer potential, while also exhibited strong antibacterial effects, with being the most effective against multidrug-resistant bacteria strains. These Schiff bases also inhibit biofilm formation, suggesting their potential for treating biofilm-related infections. analyses of their ADME properties, global reactivity descriptors, and binding affinities corroborated these findings. The Schiff base has a strong binding affinity for DNA gyrase and vitamin D receptor, suggesting potential mechanisms for its antibacterial and anticancer activities.
Scopus© Citations 15
Some of the metrics are blocked by your
consent settings
Bioactive Composition of Tropical Flowers and Their Antioxidant and Antimicrobial Properties
(MDPI AG, 2024-11-24)
Elena Coyago-Cruz
;
Alejandro Barrigas
;
Aida Guachamin
;
HEREDIA MOYA, JORGE HUMBERTO
;
ZUÑIGA MIRANDA, JOHANA JANINA
This study evaluated tropical flower petals’ bioactive compounds and antioxidant and antimicrobial properties. The physicochemical characteristics, carotenoids, phenolics, anthocyanins, organic acids, and antioxidant activity of 67 flowers were analyzed. In addition, the antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus mutans, Candida albicans, and Candida tropicalis of 35 species was determined. A 2 × 3 experimental design was used for the extraction of carotenoids and phenolics, including solvents and ultrasonic agitation times. The mixture of methanol–acetone–dichloromethane (1:1:2) and acetone–methanol (2:1) resulted in the highest concentration of carotenoids, while acidified 80% methanol favoured phenolic extraction. Renealmia alpinia was extremely rich in carotenoids (292.5 mg β-carotene/g DW), Pleroma heteromallum in anthocyanins (7.35 mg C-3-gl/g DW), while a high content of citric acid was found in Hibiscus rosa-sinensis (17,819 mg/100 g DW). On the other hand, Thibaudia floribunda showed the highest antioxidant activity (7.8 mmol Trolox equivalent/g DW). The main phenolics were m-coumaric acid in Acalypha poiretii (12,044 mg/100 g DW), 4-hydroxybenzoic acid in Brugmansia arborea (10,729 mg/100 g DW), and kaempferol in Dahlia pinnata (8236 mg/100 g DW). The extract of Acalypha poiretii, Brownea macrophylla, and Cavendishia nobilis showed antibacterial activity, while the extract of Pleroma heteromallum was the only one active against Candida albicans. These findings highlight the potential health benefits from certain tropical flowers.
Scopus© Citations 12
Some of the metrics are blocked by your
consent settings
Synthesis and Evaluation of Biological Activities of Bis(spiropyrazolone)cyclopropanes: A Potential Application against Leishmaniasis
(MDPI AG, 2021-08-17)
Olalla Barreiro-Costa
;
Gabriela Morales-Noboa
;
Patricio Rojas-Silva
;
Eliana Lara-Barba
;
Javier Santamaría-Aguirre
<jats:p>This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We then characterized their potential application in therapeutic use. For this, the in vitro biological activities against three eukaryotic models—S. cerevisiae, five cancer cell lines, and the parasite L. mexicana—were evaluated. In addition, cytotoxicity against non-cancerous mammalian cells has been evaluated and other properties of interest have been characterized, such as genotoxicity, antioxidant properties and, in silico predictive adsorption, distribution, metabolism, and excretion (ADME). The results that we present here represent a first screening, indicating two derivatives of bis(spiropyrazolone)cyclopropanes as good candidates for the treatment of leishmaniasis. They have good specificity against parasites with respect to mammalian cells.</jats:p>
Scopus© Citations 6
Some of the metrics are blocked by your
consent settings
Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities
(Springer Science and Business Media LLC, 2021-06-03)
José Eduardo Cadena-Cruz
;
Luis M. Guamán-Ortiz
;
Juan Carlos Romero-Benavides
;
Natalia Bailon-Moscoso
;
Kevin E. Murillo-Sotomayor
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several drugs currently on the market have this heterocycle as the key structural motif, and some have been approved for the treatment of different types of cancer.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>4,4ʹ-(Arylmethylene)bis(1<jats:italic>H</jats:italic>-pyrazol-5-ols) derivatives <jats:bold>3a</jats:bold>–<jats:bold>q</jats:bold> were synthetized by a three components reaction of 3-methyl-1-phenyl-5-pyrazolone (<jats:bold>1</jats:bold>) with various benzaldehydes <jats:bold>2</jats:bold> catalyzed by sodium acetate at room temperature. The structures of all synthesized compounds were characterized by physicochemical properties and spectral means (IR and NMR) and were evaluated for their radical scavenging activity by DPPH assay and tested in vitro on colorectal RKO carcinoma cells in order to determine their cytotoxic properties. All 4,4ʹ-(arylmethylene)bis(1<jats:italic>H</jats:italic>-pyrazol-5-ols) derivatives <jats:bold>3a</jats:bold>–<jats:bold>q</jats:bold> were synthetized in high to excellent yield, and pure products were isolated by simple filtration. All compounds have good radical scavenging activity, and half of them are more active than ascorbic acid used as standard.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Several derivatives proved to be cytotoxic in the RKO cell line. In particular, compound <jats:bold>3i</jats:bold> proved to be a very potent scavenger with an IC<jats:sub>50</jats:sub> of 6.2 ± 0.6 µM and exhibited an IC<jats:sub>50</jats:sub> of 9.9 ± 1.1 μM against RKO cell. Autophagy proteins were activated as a survival mechanism, whereas the predominant pathway of death was p53-mediated apoptosis.</jats:p> </jats:sec>
Scopus© Citations 23
Some of the metrics are blocked by your
consent settings
Green Synthesis of Silver Oxide Nanoparticles from Mauritia flexuosa Fruit Extract: Characterization and Bioactivity Assessment
(MDPI AG, 2024-11-22)
ZUÑIGA MIRANDA, JOHANA JANINA
;
David Vaca-Vega
;
Karla Vizuete
;
Saskya E. Carrera-Pacheco
;
GONZALEZ PASTOR, REBECA EUGENIA
The increasing prevalence of multidrug-resistant (MDR) pathogens, persistent biofilms, oxidative stress, and cancerous cell proliferation poses significant challenges in healthcare and environmental settings, highlighting the urgent need for innovative and sustainable therapeutic solutions. The exploration of nanotechnology, particularly the use of green-synthesized nanoparticles, offers a promising avenue to address these complex biological challenges due to their multifunctional properties and biocompatibility. Utilizing a green synthesis approach, Mauritia flexuosa Mf-Ag2ONPs were synthesized and characterized using dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy coupled with scanning electron microscopy (EDS-SEM), UV-Vis spectroscopy, and Fourier transform infrared spectroscopy (FTIR). The Mf-Ag2ONPs exhibited potent antibacterial effects against both non-resistant and MDR bacterial strains, with minimum inhibitory concentrations (MICs) ranging from 11.25 to 45 µg/mL. Mf-Ag2ONPs also demonstrated significant antifungal efficacy, particularly against Candida glabrata, with an MIC of 5.63 µg/mL. Moreover, the nanoparticles showed strong biofilm inhibition capabilities and substantial antioxidant properties, underscoring their potential to combat oxidative stress. Additionally, Mf-Ag2ONPs exhibited pronounced anticancer properties against various cancer cell lines, displaying low IC50 values across various cancer cell lines while maintaining minimal hemolytic activity at therapeutic concentrations. These findings suggest that Mf-Ag2ONPs synthesized via an eco-friendly approach offer a promising alternative for biomedical applications, including antimicrobial, antifungal, antioxidant, and anticancer therapies, warranting further in vivo studies to fully exploit their therapeutic potential.
Scopus© Citations 13

HEREDIA MOYA, JORGE HUMBERTO

Filters

Settings

Sort By

Results per page