GONZÁLEZ PASTOR, REBECA EUGENIA
Preferred name
GONZÁLEZ PASTOR, REBECA EUGENIA
Main Affiliation
CENBIO - Centro de Investigación Biomédica
Web Site
ORCID
0000-0002-5630-6645
Scopus Author ID
56516826700
17 results
Now showing 1 - 10 of 17
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Item type:Publication, Bioactive Compounds, Antioxidant, Antimicrobial and Anticancerogenic Activity in Lacmellea edulis H. Karst., at Different Stages of Maturity(MDPI AG, 2025-10-14); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Crystal Structure, Hirshfeld Surface Analysis, and Biological Activities of Schiff-Base Derivatives of 4-Aminoantipyrine(American Chemical Society (ACS), 2023-10-31); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chemical Properties and Biological Activity of Bee Pollen(MDPI AG, 2023-11-25); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phytosynthesis of Silver Nanoparticles Using Mansoa alliacea (Lam.) A.H. Gentry (Bignoniaceae) Leaf Extract: Characterization and Their Biological Activities(MDPI AG, 2024-09-25); ; ; Cristina Rodríguez-PólitBackground. Mansoa alliacea is a native plant renowned for its medicinal properties in traditional healing in the Amazon Region. This plant is rich in polyphenols, flavonoids, anthocyanins, phenolic acids, tannins, ketones, triterpenes, as well as other bioactive compounds. Objectives. This study aims to develop an innovative, eco-friendly method for synthesizing silver nanoparticles using an aqueous extract of M. alliacea (Ma-AgNPs), enhancing the biological activities of AgNPs by leveraging the therapeutic potential of the plant’s bioactive compounds. Methods. Silver nanoparticles were synthesized using the aqueous extract of M. alliacea. The biological activities of Ma-AgNPs were assessed, including antibacterial, anti-inflammatory, antioxidant, antitumor, and anti-biofilm effects, along with evaluating their hemolytic activity. Results. Quantitative analysis revealed that Ma-AgNPs exhibit potent antibacterial activity against multidrug and non-multidrug-resistant bacteria, with MIC values ranging from 1.3 to 10.0 µg/mL. The Ma-AgNPs significantly reduced NO production by 86.9% at 4 µg/mL, indicating strong anti-inflammatory effects. They demonstrated robust antioxidant activity with an IC50 of 5.54 ± 1.48 µg/mL and minimal hemolytic activity, with no hemolysis observed up to 20 µg/mL and only 4.5% at 40 µg/mL. Their antitumor properties were notable, with IC50 values between 2.9 and 5.4 µg/mL across various cell lines, and they achieved over 50% biofilm inhibition at concentrations of 30–40 µg/mL. Conclusions. These findings underscore the potential of Ma-AgNPs for biomedical applications, particularly in developing new antimicrobial agents and bioactive coatings with reduced toxicity. This research highlights a sustainable approach that not only preserves but also amplifies the inherent biological activities of plant extracts, paving the way for innovative therapeutic solutions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Bioactive Phenolic Compounds from Rambutan - Nephelium lappaceum L. - Shell: Encapsulation, Structural Stability, and Multifunctional Activities(MDPI AG, 2025-11-09); Rambutan (Nephelium lappaceum) shell, an agro-industrial by-product, is a rich source of phenolic acids and minor anthocyanins, but its direct use is limited by instability and low bioavailability. We extracted phenolic-rich fractions and produced maltodextrin microcapsules by spray drying, then confirmed chemical entrapment and amorphization by FTIR, SEM, and XRD. The formulation showed high encapsulation efficiency and high antioxidant capacity (DPPH), selective bactericidal activity against Pseudomonas aeruginosa and Burkholderia cepacia, and strong inhibition of Staphylococcus aureus and Listeria monocytogenes biofilms, while exhibiting negligible hemolysis (<2%) across tested concentrations. Antitumor effects were moderate with low selectivity in vitro, indicating that phenolic-acid-driven redox modulation may require fractionation or delivery optimization for oncology applications. Overall, spray-dried microcapsules provided structural stability and safety while concentrating multifunctional activities relevant to food and biomedical uses. By valorizing a tropical waste stream into a bioactive, hemocompatible ingredient, this work aligns with societal goals on health and sustainable production (SDG 3 and SDG 12) and offers a scalable route to deploy underutilized phenolic resources.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation(Frontiers Media SA, 2025-09-29); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Current Landscape of Methods to Evaluate Antimicrobial Activity of Natural Extracts(MDPI AG, 2023-01-20); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods(MDPI AG, 2022-07-13); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents(Springer Science and Business Media LLC, 2025-01-31); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dimerocostus strobilaceus (Caña Agria) as an Emerging Reservoir of Bioactive Metabolites with Potential Antioxidant, Antimicrobial, Anticancer and Anti-Inflammatory Health Benefits(MDPI AG, 2025-10-29);