HEREDIA MOYA, JORGE HUMBERTO

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Main Affiliation

Facultad de Ciencias de la Salud Eugenio Espejo

CENBIO - Centro de Investigación Biomédica

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ORCID

0000-0001-7620-9140

Scopus Author ID

8680066700

Now showing 1 - 10 of 31

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Synthesis, experimental and theoretical study of novel 2-haloalkyl (-CF2H, -CCl2H, -CF2CF3)-, 3-bromo and bromomethyl substituted chromones
(Elsevier BV, 2021-02)
Ena G. Narváez O
;
Pablo M. Bonilla V.
;
Daniel A. Zurita
;
Christian D. Alcívar L.
;
Sonia E. Ulic
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Synthesis, Experimental and Theoretical Study of Azidochromones
(MDPI AG, 2022-04-20)
Ena G. Narváez-Ordoñez
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Kevin A. Pabón-Carcelén
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Daniel A. Zurita
;
Pablo M. Bonilla-Valladares
;
Trosky G. Yánez-Darquea
<jats:p>A series of 2-(haloalkyl)-3-azidomethyl and 6-azido chromones has been synthetized, characterized and studied by theoretical (DFT calculations) and spectroscopic methods (UV-Vis, NMR). The crystal structure of 3-azidomethyl-2-difluoromethyl chromone, determined by X-ray diffraction methods, shows a planar framework due to extended π-bond delocalization. Its molecular packing is stabilized by F···H, N···H and O···H hydrogen bonds, π···π stacking and C–O···π intermolecular interactions. Moreover, AIM, NCI and Hirshfeld analysis evidenced that azido moiety has a significant role in the stabilization of crystal packing through weak intermolecular interactions, where analysis of electronic density suggested closed-shell (CS) interatomic interactions.</jats:p>
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Crystal Structure, Hirshfeld Surface Analysis, and Biological Activities of Schiff-Base Derivatives of 4-Aminoantipyrine
(American Chemical Society (ACS), 2023-10-31)
Esteban Aguilar-Llanos
;
Saskya E. Carrera-Pacheco
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GONZALEZ PASTOR, REBECA EUGENIA
;
Juan Carlos Romero-Benavides
;
Carlos Cevallos-Morillo
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Chemical Properties and Biological Activity of Bee Pollen
(MDPI AG, 2023-11-25)
Cristina Rodríguez-Pólit
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GONZALEZ PASTOR, REBECA EUGENIA
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Roberto Vallejo-Imbaquingo
;
Carlos Barba-Ostria
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HEREDIA MOYA, JORGE HUMBERTO
<jats:p>Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents a rich reservoir of diverse bioactive compounds with noteworthy chemical and therapeutic potential. Its extensive biological effects have been known and exploited since ancient times. Today, there is an increased interest in finding natural compounds against oxidative stress, a factor that contributes to various diseases. Recent research has unraveled a multitude of biological activities associated with bee pollen, ranging from antioxidant, anti-inflammatory, antimicrobial, and antifungal properties to potential antiviral and anticancer applications. Comprehending the extensive repertoire of biological properties across various pollen sources remains challenging. By investigating a spectrum of pollen types and their chemical composition, this review produces an updated analysis of the bioactive constituents and the therapeutic prospects they offer. This review emphasizes the necessity for further exploration and standardization of diverse pollen sources and bioactive compounds that could contribute to the development of innovative therapies.</jats:p>
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Phytosynthesis of Silver Nanoparticles Using Mansoa alliacea (Lam.) A.H. Gentry (Bignoniaceae) Leaf Extract: Characterization and Their Biological Activities
(MDPI AG, 2024-09-25)
ZUÑIGA MIRANDA, JOHANA JANINA
;
Saskya E. Carrera-Pacheco
;
GONZALEZ PASTOR, REBECA EUGENIA
;
MAYORGA RAMOS, ARIANNA CAROLINA
;
Cristina Rodríguez-Pólit
Background. Mansoa alliacea is a native plant renowned for its medicinal properties in traditional healing in the Amazon Region. This plant is rich in polyphenols, flavonoids, anthocyanins, phenolic acids, tannins, ketones, triterpenes, as well as other bioactive compounds. Objectives. This study aims to develop an innovative, eco-friendly method for synthesizing silver nanoparticles using an aqueous extract of M. alliacea (Ma-AgNPs), enhancing the biological activities of AgNPs by leveraging the therapeutic potential of the plant’s bioactive compounds. Methods. Silver nanoparticles were synthesized using the aqueous extract of M. alliacea. The biological activities of Ma-AgNPs were assessed, including antibacterial, anti-inflammatory, antioxidant, antitumor, and anti-biofilm effects, along with evaluating their hemolytic activity. Results. Quantitative analysis revealed that Ma-AgNPs exhibit potent antibacterial activity against multidrug and non-multidrug-resistant bacteria, with MIC values ranging from 1.3 to 10.0 µg/mL. The Ma-AgNPs significantly reduced NO production by 86.9% at 4 µg/mL, indicating strong anti-inflammatory effects. They demonstrated robust antioxidant activity with an IC50 of 5.54 ± 1.48 µg/mL and minimal hemolytic activity, with no hemolysis observed up to 20 µg/mL and only 4.5% at 40 µg/mL. Their antitumor properties were notable, with IC50 values between 2.9 and 5.4 µg/mL across various cell lines, and they achieved over 50% biofilm inhibition at concentrations of 30–40 µg/mL. Conclusions. These findings underscore the potential of Ma-AgNPs for biomedical applications, particularly in developing new antimicrobial agents and bioactive coatings with reduced toxicity. This research highlights a sustainable approach that not only preserves but also amplifies the inherent biological activities of plant extracts, paving the way for innovative therapeutic solutions.
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Dynamics of Bioactive Compounds and Their Relationship with Antioxidant and Antimicrobial Activity in the Pulp, Peel, and Seeds of ‘Salak’ During Ripening
(MDPI AG, 2025-10-12)
Elena Coyago-Cruz
;
Gabriela Méndez
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ZÚÑIGA MIRANDA, JOHANA JANINA
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Nubia Jami
;
Ramiro Acurio-Vásconez
Fruit is an important source of bioactive compounds, and making full use of them can contribute to the development of natural alternatives to microbial resistance. This study aimed to evaluate the dynamics of bioactive compounds and their relationship with antioxidant and antimicrobial activity in the pulp, peel, and seeds of Salacca zalacca at three stages of ripeness (M1, 30 days after flowering; M2, 90 days after flowering; and M3, 120 days after flowering). The physicochemical characteristics (weight, size, pH, soluble solids, titratable acidity, moisture, ash, and minerals) and the bioactive compounds (vitamin C, organic acids, carotenoids, chlorophylls, and phenolic compounds) were determined using liquid chromatography. Antioxidant activity was determined using the ABTS and DPPH methods, and antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus mutans, Candida albicans and Candida tropicalis. The results showed that the pulp had the highest concentrations of malic acid (8018.6 mg/100 g DW in M1); the peel in M1 had the highest concentrations of chlorogenic (705.0 mg/100 g DW), caffeic (321.0 mg/100 g DW) and ferulic acids (173.5 mg/100 g DW); and the seeds had the highest levels of vitamin C (16.81 mg/100 g DW in M2). The pulp in M2 and M3 and the peel in M2 exhibited the highest antioxidant capacity (5.5 mmol ET/100 g DW by DPPH), as well as the most potent antimicrobial activity against S. aureus and E. coli. In conclusion, the peel, in addition to the edible pulp, represents a relevant source of bioactive compounds with potential applications in functional foods and natural products.
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Functional, Antioxidant, Antibacterial, and Antifungal Activity of Edible Flowers
(MDPI AG, 2024-10-25)
Elena Coyago-Cruz
;
Alejandro Alarcón
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Aida Guachamin
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Gabriela Méndez
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Edison Osorio
Edible flowers have been used since ancient times, but their potential for improving human health has not been explored. This study aimed to evaluate the profile of bioactive compounds (organic acids, phenolics, and carotenoids) and the antioxidant and antimicrobial activity of nine flower varieties with high concentrations of carotenoids or total phenolic compounds. Ninety-three edible flowers were analysed for physicochemical characteristics, total phenolic and carotenoid concentrations, and antioxidant activity (ABTS). Bioactive profiles were determined by rapid resolution liquid chromatography (RRLC), and antimicrobial activity was determined against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus mutans, and Candida albicans and Candida tropicalis. Chrysanthemum x hybrid orange, Helianthus annuus yellow, Tagetes patula orange, Canna indica red, and Hibiscus rosa-sinensis (orange1 and yellow) showed significant concentrations of total carotenoids. In contrast, Pelargonium hortorum orange2, Hibiscus rosa-sinensis red1, and Rosa x hybrid variety medium yellow showed high levels of total phenolics. The predominant compounds in these species were citric acid (991.4 mg/g DW in Hibiscus rosa-sinensis red1), 4-hydroxybenzoic acid (936.2 mg/100 g DW in P. hortorum orange2), kaempferol (971. 9 mg/100 g DW in T. patula orange), quercetin glucoside (958.8 in C. x hybrid), quercetin (919.3 mg/100 g DW in T. patula), α-carotene, and β-carotene in T. patula orange (989.5 and 601.2 mg/100 g DW, respectively). Regarding antimicrobial activity, T. patula orange and P. hortorum orange2 inhibited bacterial growth, while C. x hybrid orange and P. hortorum orange2 inhibited Candida albicans, and the latter inhibited Candida tropicalis. These results indicate the potential of edible flowers as a natural source of bioactive compounds and as a tool in the fight against antimicrobial resistance.
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Bioactive Compound Profiling and Antioxidant Activity of Phytelephas tenuicaulis and Other Amazonian Fruits
(MDPI AG, 2024-07-07)
Elena Coyago-Cruz
;
David Valenzuela
;
Aida Guachamin
;
Gabriela Méndez
;
HEREDIA MOYA, JORGE HUMBERTO
The Amazon region is home to many plant species, many of which have not been studied. The objective was to evaluate the physicochemical properties, bioactive compounds, and antioxidant activity of Phytelephas tenuicalis (tintiuk), Grias neuberthii (apai), Euterpe oleracea (acai), and Mauritia flexuosa (brown moriche). Physicochemical analyses were carried out on fresh fruit from local markets. Bioactive compounds (carotenoids, phenolics, vitamin C, and organic acids) were quantified in the freeze-dried pulp by rapid-resolution liquid chromatography (RRLC), and antioxidant activity was determined by ABTS and DPPH assays. The results showed high soluble solids (10.7 °Brix) and ascorbic acid (67.3 mg/100 g DW) in tintiuk; β-carotene (63.4 mg/100 g DW) and malic acid (19.6 g/100 g DW) in brown moriche; quercetin (944.2 mg/100 g DW) and antioxidant activity by ABTS (6.7 mmol ET/100 g DW) in apai; and citric acid (2.1 g/100 g DW) in acai. These results indicate interesting bioactive properties that could increase the consumption of these fruits nationally and internationally, benefiting local farmers and stimulating the development of new products in functional food, medicine, and cosmetics.
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Synthesis and Evaluation of Biological Activities of Bis(spiropyrazolone)cyclopropanes: A Potential Application against Leishmaniasis
(MDPI AG, 2021-08-17)
Olalla Barreiro-Costa
;
Gabriela Morales-Noboa
;
Patricio Rojas-Silva
;
Eliana Lara-Barba
;
Javier Santamaría-Aguirre
<jats:p>This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We then characterized their potential application in therapeutic use. For this, the in vitro biological activities against three eukaryotic models—S. cerevisiae, five cancer cell lines, and the parasite L. mexicana—were evaluated. In addition, cytotoxicity against non-cancerous mammalian cells has been evaluated and other properties of interest have been characterized, such as genotoxicity, antioxidant properties and, in silico predictive adsorption, distribution, metabolism, and excretion (ADME). The results that we present here represent a first screening, indicating two derivatives of bis(spiropyrazolone)cyclopropanes as good candidates for the treatment of leishmaniasis. They have good specificity against parasites with respect to mammalian cells.</jats:p>
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Phytochemical Composition and Biological Properties of Macleania rupestris Fruit Extract: Insights into Its Antimicrobial and Antioxidant Activity
(MDPI AG, 2025-03-27)
MAYORGA RAMOS, ARIANNA CAROLINA
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ZUÑIGA MIRANDA, JOHANA JANINA
;
Elena Coyago-Cruz
;
HEREDIA MOYA, JORGE HUMBERTO
;
Jéssica Guamán-Bautista
Macleania rupestris, a fruit-bearing species of the Ericaceae family, has traditionally been used for its potential medicinal properties. Background/Objectives: This study investigates the phytochemical composition and antimicrobial activity of M. rupestris fruit extract, focusing on its antibacterial, antibiofilm, and antifungal effects. Methods: M. rupestris (Kunth) A.C.Sm. berries (code: 4456, Herbario QUPS-Ecuador) were collected from the cloud forest Montano Alto, Cuenca-Ecuador, and the extract was obtained using an ethanolic-based extraction and chemically characterized. The antibacterial and antifungal activity of the fruit extract was assessed against seven multidrug-resistant bacteria strains and four fungal strains using the microdilution method. The biofilm inhibition potential was evaluated using a microplate assay with the crystal violet staining method. The antioxidant activity was evaluated using DPPH and ABTS assays. Results: The bioactive compounds showed 853.9 mg phenols/100 g DW, 573.2 mg organic acid/100 g DW, and 21.5 mg C-3-gl/100 g DW of anthocyanins. The antibacterial assays demonstrated significant inhibitory activity against Enterococcus faecalis, Enterococcus faecium, Escherichia coli, and Staphylococcus epidermidis, with MIC values ranging from 1.25 to 5 mg/mL. Additionally, the biofilm inhibition assays confirmed the potential of M. rupestris extract to disrupt bacterial biofilms, particularly in S. aureus and L. monocytogenes. Nevertheless, no significant antifungal activity was observed against Candida spp., suggesting selective antimicrobial properties. Finally, the antioxidant activity was strong (1.62 mmol TE/100 g DW by DPPH and 3.28 mmol TE/100 g DW by ABTS). Conclusions: These findings indicate that M. rupestris possesses promising antibacterial, antibiofilm, and antioxidant properties, which may be attributed to its phenolic and organic acid composition. Further fractionation and targeted bioassays are required to elucidate the specific bioactive compounds responsible for these effects and explore their potential applications in antimicrobial formulations.

HEREDIA MOYA, JORGE HUMBERTO

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