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Experimental assessment of acid gas energy recovery potential in refinery operations
(Springer Science and Business Media LLC, 2026-03-17)
Murillo-Calderon, Israel Alejandro
RUTH YESENIA
VILLACÍS JURADO, ALEXANDRA JAZMÍN
ANDREA LUCÍA
ANA CRISTINA, BÉJAR ALBÁN
SF
PUENTE, JUAN
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Case Report Series: Genetic and clinical characterization of long QT syndrome in admixed Ecuadorian patients and its implications for sudden cardiac death risk
(Frontiers Media SA, 2026-02-12)
PAZ CRUZ, ELIUS ANDRES
;
RUIZ POZO, VIVIANA ALEJANDRA
;
CADENA ULLAURI, SANTIAGO ANDRÉ
;
GUEVARA RAMÍREZ, ALEXANDRA PATRICIA
;
TAMAYO TRUJILLO, VICTOR RAFAEL
Long QT syndrome (LQTS) is a hereditary cardiac channelopathy associated with delayed ventricular repolarization and increased risk of life-threatening arrhythmias and sudden cardiac death. We report three Ecuadorian patients with LQTS, each presenting distinct clinical features and carrying pathogenic or likely pathogenic variants in KCNH2 or KCNQ1. Subject A, an 18-year-old woman with exertion-related syncope and a QTc of 520 ms, was diagnosed with LQT2 due to a KCNH2 p.Ala614Val variant. Subject B, a 3-year-old girl with congenital deafness and a QTc of 580 ms, was diagnosed with Jervell and Lange-Nielsen syndrome (JLNS), harboring a homozygous KCNQ1 p.Arg192Cys variant. Subject C, a 44-year-old man with recurrent syncope misdiagnosed as epilepsy and a strong family history of sudden death, was found to carry a KCNH2 p.Val612Met variant and had a QTc of 600 ms. All variants were classified according to ACMG/AMP guidelines and supported by in silico and functional data. Ancestry analysis provided additional genomic context in this admixed population. These cases underscore the clinical utility of integrating ECG findings, genetic testing, and ancestry-informed interpretation to improve diagnostic accuracy and personalize management in patients with inherited arrhythmia syndromes.
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Optimizing fish skin scaffolds for regenerative medicine: A comparative study of physical and chemical decellularization techniques
(Elsevier BV, 2026-05)
Esmat Azizipour
;
Hengameh Honarkar
;
Reza Yarahmadi
;
Ahmad Vaez
;
Mehdi Kian
Fish skin scaffolds have great potential as biocompatible materials for skin regeneration, as they contain high levels of collagen and are structurally similar to the mammalian extracellular matrix (ECM). In this study, we compared the efficiency of physical decellularization with chemical decellularization using sodium dodecyl sulphate (SDS), sodium lauryl ether sulfate (SLES), and Triton X-100 at two concentrations (0.5% and 1%) and two time intervals (6 and 12 h). The decellularization efficiency and quality of scaffolds were assessed via histological observations, glycosaminoglycan (GAG) content, MTT assay to evaluate cytocompatibility, scaffold degradation rate, and scanning electron microscopy (SEM) observations. Silicone membrane physical decellularization preserves the integrity of the ECM, retains higher levels of GAG (1.5 µg/mm³) and higher levels of fibroblast viability (p < 0.001) and demonstrates limited degradation (< 20% on day 14) compared to chemical decellularization. Chemical decellularization caused some breakdown of the ECM, particularly treatments at 1%-12h, and was able to retain lower levels of GAG (0.5–0.9 µg/mm³) while degrading more (up to 150%). SEM shows the scaffolds from the physical decellularization treatment had a clearer fibrous structure compared to the variable porosity of the chemical treatment.
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Cycloaddition of CO
<sub>2</sub>
and Epoxide at Ambient Conditions Catalyzed by PW
<sub>12</sub>
@HKUST-1 Composite and Optimization Study Using RSM
(American Chemical Society (ACS), 2026-02-06)
Suleiman Gani Musa
;
Zulkifli Merican Aljunid Merican
;
Abdurrashid Haruna
;
Noor Asmawati Binti Mohd Zabidi
;
Mohammad Yusuf
The search for a sustainable and effective catalyst for CO2 fixing using epoxides is part of a global quest for economical carbon capture and utilization solutions. The coupling of metal–organic frameworks (MOFs) with other functional nanomaterials such as polyoxometalates (POMs) has proven to be effective in increasing the heterogeneity and stability of pristine MOF materials. We demonstrated the application of MOF/POM-supported composites (POM@MOF) as catalysts for the fixation of CO2 and epichlorohydrin epoxide (ECH) to chloropropene carbonate. The catalyst was synthesized by impregnating HKUST-1 with (TBA)3PW12O40, a Keggin-type polyoxometalate. The obtained composite, PW12@HKUST-1, was characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy-dispersive spectroscopy (EDS), and N2 adsorption–desorption isotherms. The POM’s presence was confirmed by various analyses. Optimization of the reaction variables was conducted using the response surface methodology model. The optimum condition for the CCD-RSM studies was catalyst amount: 12.50 mg, cocatalyst amount: 0.055 mmol, temperature: 100 °C, and time: mechanism of CO2 conversion 15 h, attaining 89.70% conversion and 97% selectivity. The catalyst shows a remarkable increase in stability and reusability by recycling six times in a row without any significant decrease in catalytic activity.
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Case Report: Immune reconstitution–related neurological deterioration in advanced HIV infection with multiple opportunistic infections: a diagnostic challenge
(Frontiers Media SA, 2026-02-23)
Jesús Endara-Mina
;
Cristopher-Josué Escudero
;
Victor Samaniego
;
Karla Fuentes
;
William Tapia
Immune reconstitution inflammatory syndrome (IRIS) is a serious complication following antiretroviral therapy (ART) initiation in patients with advanced HIV infection, particularly when the central nervous system is involved and multiple opportunistic infections coexist. We report the case of a 26-year-old man with newly diagnosed advanced HIV infection who developed rapid neurological deterioration shortly after ART initiation during hospitalization. Neuroimaging revealed a necrotic central nervous system mass lesion with extensive edema and mass effect. Serological testing demonstrated prior exposure to Toxoplasma gondii and active Treponema pallidum infection. Despite broad antimicrobial therapy, corticosteroids, and supportive care, the patient experienced progressive clinical deterioration and died. Retrospective reassessment of the clinical course, imaging findings, epidemiological context, and treatment response suggested an IRIS-related inflammatory process, with central nervous system tuberculosis–associated IRIS representing the most plausible underlying mechanism, while toxoplasmosis and syphilis were considered potential concomitant or confounding conditions. This case underscores the diagnostic complexity of IRIS in advanced HIV infection and highlights the importance of a cautious, probabilistic, and evidence-based approach to avoid etiologic misclassification in severe neurological presentations.

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