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Item type:Publication, Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer(Hindawi Limited, 2017); Santiago Guerrero<jats:p>Prostate cancer (PC) is the second most commonly diagnosed type of cancer in males with 1,114,072 new cases in 2015. The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids. MTHFR C677T alters homocysteine levels and folate assimilation associated with DNA damage. Androgens play essential roles in prostate growth. The SRD5A2 enzyme metabolizes testosterone and the V89L polymorphism reduces in vivo SRD5A2 activity. The androgen receptor gene codes for a three-domain protein that contains two polymorphic trinucleotide repeats (CAG, GGC). Therefore, it is essential to know how PC risk is associated with clinical features and polymorphisms in high altitude Ecuadorian mestizo populations. We analyzed 480 healthy and 326 affected men from our three retrospective case-control studies. We found significant association between MTHFR C/T (odds ratio [OR] = 2.2;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">0.009</mml:mn></mml:math>), MTHFR C/T+T/T (OR = 2.22;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">0.009</mml:mn></mml:math>), and PC. The SRD5A2 A49T substitution was associated with higher pTNM stage (OR = 2.88;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">0.039</mml:mn></mml:math>) and elevated Gleason grade (OR = 3.15;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">0.004</mml:mn></mml:math>). Additionally, patients with ≤21 CAG repeats have an increased risk of developing PC (OR = 2.99;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M5"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.001</mml:mn></mml:math>). In conclusion, genotype polymorphism studies are important to characterize genetic variations in high altitude mestizo populations.</jats:p> - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Ancestry study in Ecuadorian population with multiple myeloma(Ovid Technologies (Wolters Kluwer Health), 2017) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Mutation rates for 29 short tandem repeat loci from the Ecuadorian population(Elsevier BV, 2017-12) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Genetic characterization of four Colombian populations using Investigator® Argus X-12 kit(Elsevier BV, 2017-12); N.D. Suarez - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Genetic data for twenty-two autosomal STRs (PowerPlex® Fusion) from Afro-Ecuadorian population(Elsevier BV, 2017-12) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular analysis of ancestry informative markers (AIMs-INDELs) in a high altitude Ecuadorian mestizo population affected with breast cancer(Elsevier BV, 2017-12); A. Cabrera-Andrade - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of ancestral membership proportions and genotype distribution in the perception of Umami taste in Ecuadorian mestizos(Elsevier BV, 2017-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies(Springer Science and Business Media LLC, 2018-09-18) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The geographic mosaic of Ecuadorian Y-chromosome ancestry(Elsevier BV, 2018-03)
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