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Item type:Publication, Phytochemical Characterization and In Vitro Biological Activities of Macleania rupestris or Ericaceae: Insights into Nutraceutical Potential(MDPI AG, 2025-10-31) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Exploring the Multifaceted Biological Activities of Anthocyanins Isolated from Two Andean Berries(MDPI AG, 2024-08-21); ; Natural pigments extracted from plant species are used in foods, cosmetics, and pharmaceuticals. This study evaluates the comprehensive biological activities of anthocyanins isolated from Andean blueberry (Vaccinium floribundum Kunth) and Andean blackberry (Rubus glaucus Benth), focusing on their antimicrobial, antioxidant, antitumoral, anti-inflammatory, and hemolytic properties. Chemical characterization revealed significant anthocyanin content with complex mass spectrometric profiles indicating diverse glycosylation patterns that may influence their bioactivity. The antimicrobial assays showed that the extracts were particularly effective against Gram-positive bacteria, with minimal inhibitory concentrations (MICs) as low as 1 mg/mL for Rubus glaucus, indicating strong potential for therapeutic use. The antioxidant capacity of the berries was substantial, albeit slightly lower than that of ascorbic acid. The extracts also exhibited notable antitumoral activity in various cancer cell lines, showing promise as adjunctive or preventive treatments. The anti-inflammatory effects were confirmed by inhibiting nitric oxide production in macrophage cells, highlighting their potential in managing inflammatory diseases. In terms of hemolytic activity, Rubus glaucus exhibited dose-dependent effects, potentially attributable to anthocyanins and phenolics, while Vaccinium floribundum demonstrated no significant hemolytic activity, underscoring its safety. These findings suggest that anthocyanins from Andean berries possess potent biological activities, which could be leveraged for health benefits in pharmaceutical and nutraceutical applications. Further studies are needed to isolate specific bioactive compounds and investigate their synergistic effects in clinical and real-world contexts. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis(Springer Science and Business Media LLC, 2017-08-08) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population(Springer Science and Business Media LLC, 2017-06-24) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Erratum to: Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population(Springer Science and Business Media LLC, 2017-09-05) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis(Springer Science and Business Media LLC, 2018-11-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis(MDPI AG, 2020-02-05); Yunierkis Pérez-Castillo<jats:p>Osteosarcoma is the most common subtype of primary bone cancer, affecting mostly adolescents. In recent years, several studies have focused on elucidating the molecular mechanisms of this sarcoma; however, its molecular etiology has still not been determined with precision. Therefore, we applied a consensus strategy with the use of several bioinformatics tools to prioritize genes involved in its pathogenesis. Subsequently, we assessed the physical interactions of the previously selected genes and applied a communality analysis to this protein–protein interaction network. The consensus strategy prioritized a total list of 553 genes. Our enrichment analysis validates several studies that describe the signaling pathways PI3K/AKT and MAPK/ERK as pathogenic. The gene ontology described TP53 as a principal signal transducer that chiefly mediates processes associated with cell cycle and DNA damage response It is interesting to note that the communality analysis clusters several members involved in metastasis events, such as MMP2 and MMP9, and genes associated with DNA repair complexes, like ATM, ATR, CHEK1, and RAD51. In this study, we have identified well-known pathogenic genes for osteosarcoma and prioritized genes that need to be further explored.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing(MDPI AG, 2020-11-22) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks(Springer Science and Business Media LLC, 2020-05-22) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Perturbation-Theory Machine Learning (PTML) Multilabel Model of the ChEMBL Dataset of Preclinical Assays for Antisarcoma Compounds(American Chemical Society (ACS), 2020-10-15)