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Salmonella enterica Serovar Infantis KPC-2 Producer: First Isolate Reported in Ecuador
Journal
Microbial Drug Resistance
ISSN
1076-6294
Date Issued
2024-12-01
Author(s)
Viviana Albán
Carolina Satán
Hidaleisy Quintana
Wladimir Enríquez
Katherine Jaramillo
Lino Arisqueta
Abstract
Antimicrobial resistance is currently considered a public health threat. Carbapenems are antimicrobials for hospital use, and Enterobacterales resistant to these β-lactams have spread alarmingly in recent years, especially those that cause health care-associated infections.
The blaKPC gene is considered one of the most important genetic determinants disseminated by plasmids, promoting horizontal gene transfer.
This study describes, for the first time in Ecuador, and worldwide, the presence of a blaKPC-2 gene in an isolate of Salmonella enterica serovar Infantis from a clinical sample.
Through whole-genome sequencing, we characterized the genetic determinants of antimicrobial resistance in this Salmonella ST-32 strain. Our results showed the presence of several resistance genes, including blaCTX-M-65, and a conjugative plasmid Kpn-WC17-007-03 that may be responsible for the horizontal transference of these resistance mechanisms.
The blaKPC gene is considered one of the most important genetic determinants disseminated by plasmids, promoting horizontal gene transfer.
This study describes, for the first time in Ecuador, and worldwide, the presence of a blaKPC-2 gene in an isolate of Salmonella enterica serovar Infantis from a clinical sample.
Through whole-genome sequencing, we characterized the genetic determinants of antimicrobial resistance in this Salmonella ST-32 strain. Our results showed the presence of several resistance genes, including blaCTX-M-65, and a conjugative plasmid Kpn-WC17-007-03 that may be responsible for the horizontal transference of these resistance mechanisms.