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A Recyclable Halide Perovskite Photocatalyst as a Single-electron Redox Mediator: Radical-initiated Gram-scale Photosynthesis of Pyrano[2,3 ]pyrimidines Induced by Visible Light
(Informa UK Limited, 2024-08-12)
Farzaneh Mohamadpour
;
Hesam Kamyab
;
Shreeshivadasan Chelliapan
;
Ali Mohammad Amani
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Alginate hydrogel film reinforced with Fe3O4@SiO2/Schiff-base/Cu(II) nanoparticles in promoting diabetic wound healing
(Elsevier BV, 2026-04)
Sedigheh Azadi
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Alireza Abbaspour
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Seyed Reza Kasaee
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Farhad Koohpeyma
;
Esmat Azizipour
In the quest to enhance diabetic wound healing, we synthesized Fe3O4@SiO2/Schiff-base complex of Cu(II) magnetic nanoparticles (MNPs) embedded in sodium alginate hydrogel. This study analyzed the effects of 1% and 10% Cu(II) nanoparticles (NPs) concentrations on wound closure and tissue regeneration in a diabetic rat model. Streptozotocin-induced diabetic Sprague-Dawley rats were used to evaluate the in vivo efficacy of NPs. Characterization involved digital photography for wound closure quantification, histopathological analysis for tissue repair assessment, and statistical methods for data interpretation. Our findings indicated that the 1% Cu nanoparticle (NP) -embedded hydrogel significantly improved wound healing, including enhanced reepithelialization, collagen deposition, neovascularization, granulation tissue formation, and fibroblast activation, while also reducing inflammation. The 10% Cu NP formulation did not demonstrate the same level of efficacy, suggesting a concentration-dependent therapeutic window for copper ion release. This novel NP hydrogel showcases the potential of copper-based NPs in diabetic wound management, offering a cost-effective and promising approach for treating a global health issue.
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Revolutionizing corrosion protection: MXenes as next-generation materials for sustainable and high-performance solutions
(Elsevier BV, 2026-01)
Ehsan Vafa
;
Reza Bazarganlari
;
Hengameh Honarkar
;
Lobat Tayebi
;
Peyman Asadi
Corrosion is a pervasive problem that has spurred the development of innovative materials and technologies aimed at mitigating its impact across industries worldwide. MXenes, a rapidly growing family of 2D transition metal carbides, nitrides, and carbonitrides, have emerged as promising candidates for corrosion protection due to their exceptional properties, including high surface area, mechanical strength, electrical conductivity, and tunable surface chemistry. This review highlights the diverse applications of MXenes in corrosion science, particularly their use as corrosion-resistant coatings, inhibitors, and sensors. We emphasize the key properties, such as barrier performance, electrochemical activity, and the ability to form protective layers, that make MXenes highly effective in combating corrosion. Specific applications, including their role in composite coatings, self-healing systems, and multifunctional inhibitors in both acidic and alkaline environments, are discussed. Additionally, the potential in electrochemical corrosion monitoring and the mitigation of specific corrosion types, such as pitting and high-temperature corrosion, were explored. While these applications demonstrate promising performance, further research is needed to address challenges related to stability, scalability, and environmental impact. This review provides a comprehensive overview of current MXene-based corrosion protection technologies, aiming to inspire further innovation and advance the practical application of MXenes in addressing one of the most significant challenges in materials science today.
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A comprehensive review on MXene nanostructures for biosensing, imaging, and therapeutic systems
(Elsevier BV, 2026-02)
Ali Mohammad Amani
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Ehsan Vafa
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Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Because of their exceptional electrical, mechanical, dimensional, chemical, and magnetic characteristics, MXenes have attracted an abundance of interest in scholarly study lately. According to recent developments and discoveries, MXene, a multilayered compound with a two-dimensional (2D) framework, has a lot greater promise for use in bioengineering and medical research than other nanosystems. These uses encompass medical procedures, administering medications, biosensor technologies, incorporation, antimicrobial agents, and biological imaging. MXenes are very attractive prospects for therapeutic, diagnostic, and theranostic use because of their distinctive features, which include their substantial conductivity to electricity, magnetic luminescence, wide extent of coverage, excellent biocompatibility, and low toxicological profile. Modifications to the MXene surfaces are biocompatible and serve a variety of purposes, such as directing ligands to certain locations for preferred aggregation, which makes them suitable for use in particular applications. A description of the properties, changes, and synthesis techniques of MXene nanostructures is presented in this work. The practical applications of MXene-derived nanostructures in biomedical fields are also thoroughly evaluated in this study, with an emphasis on implants, biosensing, biological imaging, antibacterial activities, and versatile therapeutic systems. The potential opportunities and difficulties related to the use of MXenes throughout the field of biological medicine are also covered in this paper.
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Effect of Bioactive Glass on PXDDA - PXDDA-co-PLA Nanocomposite for Hard Tissue Reconstruction: Synthesis and Characterization
(Elsevier BV, 2025-05)
Ehsan Vafa
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Lobat Tayebi
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Fatemeh Azizli
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Somayeh Parham
;
Katayoon Rezaeeparto
Newer bone graft materials face various challenges in achieving optimal mechanical strength, bioactivity, and antibacterial action simultaneously, which can result in suboptimal regeneration outcomes and increased infection risks In the present study, we developed a novel nanocomposite of poly (xylitol- co -dodecanedioic acid) (PXDDA) and poly (lactic acid) (PLA) with 1–10 wt% incorporation of bioactive glass (BG), utilizing a a PXDDA-co-PLA compatibilizer for maintaining homogeneity. Extensive characterization techniques including, Fourier infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauere Emmette Teller (BET), Proton Nuclear Magnetic Resonance (1H NMR) and contact angle measurements, revealed that the addition of BG imparted a microporous, rough surface morphology (with a contact angle of 55–60°), ideal for cell attachment. Mechanical testing demonstrated a significant enhancement with 10 wt% BG, increasing tensile strength by approximately 120 % while reducing elongation. In vitro bioactivity tests indicated that hydroxyapatite deposition depended on BG concentration, reaching a maximum of 96.7 % surface coverage at 10 wt% BG. Antibacterial action against Staphylococcus aureus and Escherichia coli confirmed substantial inhibition (approximately 85 % decrease), with saturation occurring at 7 wt% BG. With tunable mechanical properties, enhanced biomineralization, and intrinsic antibacterial capacity, this nanocomposite overcomes the significant limitations of existing bone grafts, providing a clinically viable load-bearing alternative.
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Ethylenediamine diacetate- and 2-aminopyridine-catalyzed metal-free synthesis of pyran-annulated heterocyclic systems via a domino Knoevenagel–Michael cyclocondensation reaction: an environmentally responsible approach
(Springer Science and Business Media LLC, 2025-12-03)
Farzaneh Mohamadpour
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Ali Mohammad Amani
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HESAM, KAMYAB
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Saravanan Rajendran
This study created safe and easy methods to make 2-amino-4H-chromene scaffolds and pyrano[2,3-d]pyrimidine scaffolds that are safe for the environment. The process uses a special chemical reaction called a domino Knoevenagel-Michael cyclocondensation reaction. Ethylenediamine diacetate (EDDA) is a cost-effective and inexpensive catalyst for the preparation of 2-amino-4H-chromene scaffolds and pyrano[2,3-d]pyrimidine scaffolds. The reaction happens at room temperature under solvent-free conditions. This process uses ideas from green chemistry. This study also presents a convenient method to create 2-amino-4H-chromene scaffolds. The strategy uses 2-aminopyridine, which is a cheap and recoverable catalyst, to help accelerate a reaction while refluxing in ethanol. The current method has many great benefits that support eco-friendly and sustainable chemistry. The 2-aminopyridine was stable enough to be reused four times in a row without losing its performance. The reactions finish faster and produce good-to-high results. These eco-friendly methods use safe chemicals. There is no need to use column chromatography to separate the mixture. These ways are cheap and simple to do. They put all the steps together in one pot, which makes them easier to use and better for the environment, which helps them fulfill industry demands.
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Biomedical MXene-polymer nanocomposites: advancing photothermal therapy, antibacterial action, and smart drug delivery: a review
(Elsevier BV, 2025-06)
Ali Mohammad Amani
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Lobat Tayebi
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Ehsan Vafa
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Mohammad Javad Azizli
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Milad Abbasi
MXenes are hydrophilic, conductive, tunable, and biocompatible two-dimensional ceramic materials prepared by etching the 'A' layer from their precursor MAX phases. Although MXenes show exceptional promise in photothermal therapy, biosensing, and regenerative medicine, they face challenges such as oxidative instability in physiological environments, limited drug-loading capacity, and unpredictable immune responses. To address these limitations, MXene/polymer nanocomposites incorporating both synthetic polymers (e.g., polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and polylactic-co-glycolic acid (PLGA)) and natural biopolymers (e.g., cellulose nanofiber, gelatin, chitosan, hyaluronic acid, and soybean phospholipids) have been developed. These composites enhance functionality for biomedical applications such as photothermal cancer therapy, biosensors, antibacterial agents, bone regeneration, and targeted drug delivery. The hydrophilic nature of MXenes makes them suitable for transformation into metallic-conductive electrodes, while their compatibility with metals, ceramics, and polymers improves performance in advanced applications. This review paper discusses the properties, synthesis methods, and biomedical applications of MXene/polymer nanocomposites, emphasizing the roles of both synthetic and natural biopolymers. Key achievements include near-infrared (NIR) absorption for efficient drug delivery, anticancer activity, bioimaging, and antimicrobial effects. In addition, the limitations of these nanocomposites and potential solutions are examined.
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Enhancement of mechanical properties in ethylene propylene diene monomer/natural rubber nanocomposites through Ti3C2TX reinforcement and EPDM-g-MAH compatibilization
(Elsevier BV, 2025-08)
Ali Mohammad Amani
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Lobat Tayebi
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Katayoon Rezaeeparto
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Somayeh Parham
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Mohammad Javad Azizli
This research explores elastomeric nanocomposites consisting of ethylene propylene diene monomer rubber/natural rubber (NR/EPDM) in various ratios (100:0, 80:20, 60:40, 40:60, 20:80, and 0:100 phr). The study incorporates EPDM grafted maleic anhydride (EPDM-g-MAH) as a compatibilizer, along with different quantities of Ti3C2TX reinforcement (1, 3, 5, 7, and 10 phr). To assess the dispersion and morphology of Ti₃C₂TX reinforcement in the NR/EPDM matrix, this study employed transmission electron microscopy (TEM) and scanning electron microscopy (SEM). These analyses revealed that, in the presence of EPDM-g-MAH, higher Ti3C2TX concentrations led to rougher fracture surfaces in the samples, indicating the excellent dispersion of Ti3C2TX in the NR/EPDM matrix. The investigation of mechanical and rheological properties demonstrated significant enhancements with increasing Ti3C2TX concentration in conjunction with EPDM-g-MAH. The study further explored the relationships between the nanocomposites' morphology and their theoretical and experimental mechanical properties through Mori-Tanaka analysis and dynamic mechanical thermal analysis (DMTA), respectively. These analyses revealed a strong correlation between theory and experimentation. The mechanical behavior of the composites exhibited notable improvements in tensile strength, hardness, modulus, elongation at break, and fatigue strength with the addition of Ti3C2TX, particularly in the presence of EPDM-g-MAH. Ultimately, our findings highlight the compatibility between theoretical analyses and experimental outcomes, validating the efficacy of Ti3C2TX incorporation in enhancing the properties of nanocomposites.
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MXenes in tissue engineering and regenerative medicine: Advances, challenges, and future perspectives
(Elsevier BV, 2025-10)
Ali Mohammad Amani
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Lobat Tayebi
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Ehsan Vafa
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Mohammad Javad Azizli
;
Milad Abbasi
The appealing charm of two-dimensional (2D) materials has sparked a wave of innovation across diverse scientific domains, particularly in the realm of biomedical and therapeutic applications. Among these remarkable materials, MXenes stand out as transition metal nitrides and carbides endowed with extraordinary properties. Boasting low toxicity, expansive surface area, antibacterial prowess, biocompatibility, hydrophilicity, and impressive electrical conductivity, MXenes hold immense promise for a myriad of biomedical applications from bioimaging to cancer therapy and beyond. Despite their vast potential, challenges persist in ensuring controlled drug release, stability in physiological milieus, and biodegradability. By harnessing the transformative power of nanomedicine, meticulously crafted MXene ultra-thin nanosheets emerge as versatile inorganic nanosystems primed for diverse biomedical roles. Positioned as optimal candidates for regenerative medicine and tissue engineering, MXenes mark a new age of healthcare innovation. This article delves into the latest strides made in leveraging 2D MXenes for cutting-edge regenerative medicine and tissue engineering applications while shedding light on the formidable obstacles and promising future vistas awaiting exploration with these extraordinary materials.
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Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery
(Elsevier BV, 2025-07-01)
Milad Abbasi
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Hossein Aghamollaei
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Ahmad Vaez
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Ali Mohammad Amani
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HESAM, KAMYAB
The distinctive benefits and drawbacks of various drug delivery strategies to supply corneal tissue improvement for sense organs have been the attention of studies worldwide in recent decades. Static and dynamic barriers of ocular tissue prevent foreign chemicals from entering and inhibit the active absorption of therapeutic medicines. The distribution of different medications to ocular tissue is one of the most appealing and demanding tasks for investigators in pharmacology, biomaterials, and ophthalmology, and it is critical for cornea wound healing due to the controlled release rate and increased drug bioavailability. It should be mentioned that the transport of various types of medications into the different sections of the eye, particularly the cornea, is exceedingly challenging because of its distinctive structure and various barriers throughout the eye. Nanoparticles are being studied to improve medicine delivery strategies for ocular disease. Repetitive corneal drug delivery using biodegradable nanocarriers allows a medicine to remain in different parts of the cornea for extended periods of time and thus improve administration route effectiveness. In this review, we discussed eye anatomy, ocular delivery barriers, as well as the emphasis on the biodegradable nanomaterials ranging from organic nanostructures, such as nanomicelles, polymers, liposomes, niosomes, nanowafers, nanoemulsions, nanosuspensions, nanocrystals, cubosomes, olaminosomes, hybridized NPs, dendrimers, bilosomes, solid lipid NPs, nanostructured lipid carriers, and nanofiber to organic nanomaterials like silver, gold, and mesoporous silica nanoparticles. In addition, we describe the nanotechnology-based ophthalmic medications that are presently on the market or in clinical studies. Finally, drawing on current trends and therapeutic approaches, we discuss the challenges that innovative optical drug delivery systems confront and propose future research routes. We hope that this review will serve as a source of motivation and inspiration for developing innovative ophthalmic formulations.

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