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    Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies
    (Informa UK Limited, 2025-05-06)
    Reytor-gonzález Claudia  
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    Simancas-racines Daniel  
    ;
    Campuzano Donoso Martín
    ;
    Castano Jimenez Janeth C.
    ;
    Román-galeano Náthaly Mercedes
    Metabolic dysfunction-associated steatotic liver disease is a growing global health issue linked to obesity, insulin resistance, and metabolic syndrome. Diet plays a key role in its progression and management. This narrative review highlights evidence-based nutritional strategies, including the Mediterranean diet, low-carbohydrate and ketogenic diets, and high-fiber intake, which improve insulin sensitivity, reduce hepatic fat, and lower inflammation. Nutritional deficiencies, such as low vitamin D, choline, and omega-3 levels, exacerbate metabolic dysfunction-associated steatotic liver disease, emphasizing the need for targeted supplementation. Emerging approaches, including gut microbiota modulation, precision nutrition, and nutraceuticals like resveratrol and curcumin, offer promising therapeutic potential. A multidisciplinary approach integrating dietary and lifestyle modifications is essential for effective metabolic dysfunction-associated steatotic liver disease management.
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    Effect of diet on the microbiota and immune system in patients with systemic lupus erythematosus
    (Informa UK Limited, 2024-11-30)
    RUIZ POZO, VIVIANA ALEJANDRA  
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    PAZ CRUZ, ELUIS ANDRES  
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    CADENA ULLAURI, SANTIAGO ANDRE  
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    TAMAYO TRUJILLO, VICTOR RAFAEL  
    ;
    GUEVARA RAMIREZ, ALEXANDRA PATRICIA  
    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and organ damage. Studies indicate that diet significantly influences the gut microbiota, which, in turn, affects the immune system. This article explores gut microbiota dysbiosis in SLE patients and potential mechanisms related to dietary interventions and immune function. It highlights specific dietary patterns, such as a high-fibre diet and the Mediterranean diet, that may modulate the diversity and activity of the gut microbiota. The interaction between altered microbiota and immune responses, including the regulation of inflammatory cytokines, intestinal barrier permeability, and autoantibody production is examined. This review highlights the importance of personalized dietary strategies to modulate the diversity and activity of the gut microbiota by enhancing the immune response and potentially mitigating disease progression.
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    Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review
    (Frontiers Media SA, 2024-04-03)
    ZAMBRANO ESPINOSA, ANA KARINA  
    ;
    Elius Paz-Cruz
    ;
    Viviana A. Ruiz-Pozo
    ;
    Santiago Cadena-Ullauri
    ;
    Rafael Tamayo-Trujillo
    The review present data on the intricate relationship between bariatric surgery, gut microbiota, and metabolic health in obesity treatment. Bariatric surgery, is recognized as an effective intervention for managing morbid obesity, including various techniques with distinct mechanisms of action, efficacy, and safety profiles including Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Laparoscopic Adjustable Gastric Banding (LAGB), and Biliopancreatic Diversion (BPD). RYGB and SG are the most prevalent procedures globally, inducing gut microbiota changes that influence microbial diversity and abundance. Post-surgery, alterations in bacterial communities occur, such as the increased of <jats:italic>Escherichia coli inversely correlated with fat mass and leptin levels. During digestion, microbiota produce physiologically active compounds like bile acids (Bas) and short-chain fatty acids (SCFAs). SCFAs, derived by microbial fermentation, influence appetite, energy metabolism, and obesity-related pathways. Bas, altered by surgery, modulate glucose metabolism and insulin sensitivity. Furthermore, SG and RYGB enhance incretin secretion, particularly glucagon-like peptide 1 (GLP-1). Therefore, understanding microbiota changes after bariatric surgery could be crucial for predicting metabolic outcomes and developing targeted interventions for obesity management.