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SIMANCAS RACINES, DANIEL ALEJANDRO

Preferred name

Main Affiliation

Facultad de Ciencias de la Salud Eugenio Espejo

ORCID

0000-0002-3641-1501

Scopus Author ID

48561655900

Now showing 1 - 10 of 80

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Signals for Muscular Protein Turnover and Insulin Resistance in Critically Ill Patients: A Narrative Review
(MDPI AG, 2023-02-21)
Sebastián P. Chapela
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SIMANCAS RACINES, DANIEL ALEJANDRO
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Martha Montalvan
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Evelyn Frias-Toral
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Alison Simancas-Racines
<jats:p>Sarcopenia in critically ill patients is a highly prevalent comorbidity. It is associated with a higher mortality rate, length of mechanical ventilation, and probability of being sent to a nursing home after the Intensive Care Unit (ICU). Despite the number of calories and proteins delivered, there is a complex network of signals of hormones and cytokines that affect muscle metabolism and its protein synthesis and breakdown in critically ill and chronic patients. To date, it is known that a higher number of proteins decreases mortality, but the exact amount needs to be clarified. This complex network of signals affects protein synthesis and breakdown. Some hormones regulate metabolism, such as insulin, insulin growth factor glucocorticoids, and growth hormone, whose secretion is affected by feeding states and inflammation. In addition, cytokines are involved, such as TNF-alpha and HIF-1. These hormones and cytokines have common pathways that activate muscle breakdown effectors, such as the ubiquitin–proteasome system, calpain, and caspase-3. These effectors are responsible for protein breakdown in muscles. Many trials have been conducted with hormones with different results but not with nutritional outcomes. This review examines the effect of hormones and cytokines on muscles. Knowing all the signals and pathways that affect protein synthesis and breakdown can be considered for future therapeutics.</jats:p>
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Recommendations for SARS-CoV-2/COVID-19 testing: a scoping review of current guidance
(BMJ, 2021-01)
Ingrid Arevalo-Rodriguez
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Pamela Seron
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Diana Buitrago-García
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Agustin Ciapponi
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Alfonso Muriel
<jats:sec><jats:title>Background</jats:title><jats:p>Testing used in screening, diagnosis and follow-up of COVID-19 has been a subject of debate. Several organisations have developed formal advice about testing for COVID-19 to assist in the control of the disease. We collated, delineated and appraised current worldwide recommendations about the role and applications of tests to control SARS-CoV-2/COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We searched for documents providing recommendations for COVID-19 testing in PubMed, EMBASE, LILACS, the Coronavirus Open Access Project living evidence database and relevant websites such as TRIP database, ECRI Guidelines Trust, the GIN database, from inception to 21 September 2020. Two reviewers applied the eligibility criteria to potentially relevant citations without language or geographical restrictions. We extracted data in duplicate, including assessment of methodological quality using the Appraisal of Guidelines for Research and Evaluation-II tool.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We included 47 relevant documents and 327 recommendations about testing. Regarding the quality of the documents, we found that the domains with the lowest scores were ‘Editorial independence’ (Median=4%) and ‘Applicability’ (Median=6%). Only six documents obtained at least 50% score for the ‘Rigour of development’ domain. An important number of recommendations focused on the diagnosis of suspected cases (48%) and deisolation measures (11%). The most frequently recommended test was the reverse transcription-PCR (RT-PCR) assay (87 recommendations) and the chest CT (38 recommendations). There were 22 areas of agreement among guidance developers, including the use of RT-PCR for SARS-Cov-2 confirmation, the limited role of bronchoscopy, the use chest CT and chest X-rays for grading severity and the co-assessment for other respiratory pathogens.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This first scoping review of recommendations for COVID-19 testing showed many limitations in the methodological quality of included guidance documents that could affect the confidence of clinicians in their implementation. Future guidance documents should incorporate a minimum set of key methodological characteristics to enhance their applicability for decision making.</jats:p></jats:sec>
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Ecuadorian Cancer Patients’ Preference for Information and Communication Technologies: Cross-Sectional Study
(JMIR Publications Inc., 2018-02-20)
Ivan Cherrez Ojeda
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Emanuel Vanegas
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Michell Torres
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Juan Carlos Calderón
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Erick Calero
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Thyroid cancer in Ecuador: A genetic variants review and a cross-sectional population-based analysis before and after COVID-19 pandemic
(Elsevier BV, 2024-01)
PAZ CRUZ, ELUIS ANDRES
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CADENA ULLAURI, SANTIAGO ANDRE
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Rafael Tamayo-Trujillo
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GUEVARA RAMIREZ, ALEXANDRA PATRICIA
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RUIZ POZO, VIVIANA ALEJANDRA
Objectives: The purpose of this study is to describe the genetic variants present in the Ecuadorian population and the incidence and mortality patterns of thyroid cancer in Ecuador from 2016 to 2021. Methods: The present research constitutes a nationwide cross-sectional study encompassing all reported cases of thyroid cancer (C-73) in Ecuador from 2016 to 2021. Incidence rates were calculated based on the annual population at risk, considering factors such as ethnicity, sex, age group, and the geographic location of the incidence. All data was collected from the Hospital Discharge Statistics and the Statistical Registry of General Deaths Databases. Results: Between 2016 and 2021, a total of 20,297 hospital admissions and 921 deaths attributed to thyroid cancer were reported in Ecuador. The incidence of thyroid cancer remained relatively stable from 2016 to 2019. However, there was a notable decrease in 2020, followed by an increase in 2021. Notably, thyroid cancer prevalence rates were found to be higher in highlands regions. Moreover, two genetic variants, the BRAFV600E and KITL678F, have been identified in the Ecuadorian population. It is noteworthy that women exhibited a higher susceptibility to thyroid cancer, being five times more likely than men to develop this condition. Conclusion: Ecuador exhibits one of the highest global incidences of thyroid cancer. Consequently, describing the genetic variants and epidemiological characteristics of thyroid cancer is imperative for enhancing healthcare access and formulating evidence-based public health policies. This research contributes towards a comprehensive understanding of thyroid cancer in the Ecuadorian context, aiming to improve targeted interventions and health outcomes.
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Obstructive sleep apnea knowledge and attitudes among recent medical graduates training in Ecuador
(Mattioli1885, 2018-02-21)
Iván Chérrez-Ojeda
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Juan Carlos Calderón
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Andrea Fernández García
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Donna B. Jeffe
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Ilka Santoro
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Association between the use of electronic cigarettes and myocardial infarction in U.S. adults
(Springer Science and Business Media LLC, 2024-08-05)
María José Farfán Bajaña
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Juan Carlos Zevallos
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Ivan Chérrez-Ojeda
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Geovanny Alvarado
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Tiffany Green
Background: Compared with conventional cigarettes, electronic cigarettes are less harmful in some studies. However, recent research may indicate the opposite. This study aimed to determine whether e-cigarette use is related to myocardial health in adults in the U.S. Methods: This study used data from the 2020 Behavioral Risk Factor Surveillance System (BRFSS), a cross-sectional survey of adult US residents aged 18 years or older. We examined whether e-cigarette use was related to myocardial infarction byapplying a logistic regression model to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: The final analytical sample included 198,530 adults in the U.S. Logistic regression indicated that U.S. adults who reported being former and some days of e-cigarette use had 23% and 52% greater odds of ever having an MI, respectively, than did those who reported never using e-cigarettes (OR = 1.23, 95% CI 1.08–1.40, p = 0.001; OR = 1.52, 95% CI 1.10–2.09, p = 0.010). Conclusions: The results suggest that former and someday users of e-cigarettes probably have increased odds of myocardial infarction in adults in the U.S. Further research is needed, including long-term follow-up studies on e-cigarettes, since it is still unknown whether they should be discouraged.
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Síndrome metabólico y urticaria crónica
(Colegio Mexicano de Inmunologia Clinica y Alergia, A. C., 2018-10-16)
Iván Chérrez-Ojeda
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SIMANCAS RACINES, DANIEL ALEJANDRO
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Leonardo Greiding
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Iván Tinoco-Morán
<jats:p>Hemos leído el artículo original titulado: “Calidad de vida en urticaria crónica y su relación con el impacto económico y control de la enfermedad en pacientes atendidos en el Hospital Universitario de Monterrey, México”, realizado por Arias-Cruz et al. En este interesante artículo, los autores encontraron que 72.2 % de los pacientes con urticaria crónica tiene obesidad y sobrepeso. Dado que México es uno de los países con mayor número de habitantes con problemas de peso (70 % de la población adulta padece sobrepeso u obesidad), estos hallazgos tendrían una implicación en el manejo de los pacientes con urticaria crónica. Incluso, los autores detallan prevalencias de 17 % para hipertensión arterial (más del doble que estudios internacionales) y de 30 % para síndrome metabólico en pacientes con urticaria crónica, lo cual podría estar asociado a urticaria más severa y no controlada</jats:p>
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Genomic analysis of an Ecuadorian individual carrying an SCN5A rare variant
(Springer Science and Business Media LLC, 2024-07-27)
CADENA ULLAURI, SANTIAGO ANDRE
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GUEVARA RAMIREZ, ALEXANDRA PATRICIA
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Rita Ibarra-Castillo
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José Luis Laso-Bayas
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RUIZ POZO, VIVIANA ALEJANDRA
Background: Ion channels, vital transmembrane protein complexes, regulate ion movement within cells. Germline variants in channel-encoding genes lead to channelopathies. The sodium channels in cardiac cells exhibit a structure of an alpha subunit and one to two beta subunits. The alpha subunit, encoded by the SCN5A gene, comprises four domains. Case presentation: A fifteen-year-old Ecuadorian female with atrial flutter and abnormal sinus rhythm with no familial history of cardiovascular disease underwent NGS with the TruSight Cardio kit (Illumina). A likely pathogenic SCN5A gene variant (NM_188056.2:c.2677 C > Tp. Arg893Cys) was identified, associated with arrhythmias, long QT, atrial fibrillation, and Brugada syndrome. Ancestral analysis revealed a predominant European component (43.9%), followed by Native American (35.7%) and African (20.4%) components. Conclusions: The participant presents atrial flutter and conduction disorders, despite lacking typical cardiovascular risk factors. The proband carries a SCN5A variant that has not been previously reported in Latin America and may be associated to her phenotype. The documented arginine-to-cysteine substitution at position 893 in the protein is crucial for various cellular functions. The subject’s mixed genetic composition highlights potential genetic contributors to atrial flutter, emphasizing the need for comprehensive genetic studies, particularly in mixed populations like Ecuadorians. This case underscores the importance of genetic analysis for personalized treatment and the significance of studying diverse genetic backgrounds in understanding cardiovascular diseases.
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Pharmacological interventions for treating heart failure in patients with chagas cardiomyopathy
(2012)
Hidalgo, R.
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Martí-Carvajal, A.J.
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Kwong, J.S.
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SIMANCAS RACINES, DANIEL ALEJANDRO
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Nicola, S.
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Syntheses of biomedical information: narrative reviews, systematic reviews and emerging formats
(Medwave Estudios Limitada, 2018-11-29)
Juan Víctor Ariel Franco
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Marcelo Arancibia
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SIMANCAS RACINES, DANIEL ALEJANDRO
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Eva Madrid

SIMANCAS RACINES, DANIEL ALEJANDRO

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