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Alginate hydrogel film reinforced with Fe3O4@SiO2/Schiff-base/Cu(II) nanoparticles in promoting diabetic wound healing
(Elsevier BV, 2026-04)
Sedigheh Azadi
;
Alireza Abbaspour
;
Seyed Reza Kasaee
;
Farhad Koohpeyma
;
Esmat Azizipour
In the quest to enhance diabetic wound healing, we synthesized Fe3O4@SiO2/Schiff-base complex of Cu(II) magnetic nanoparticles (MNPs) embedded in sodium alginate hydrogel. This study analyzed the effects of 1% and 10% Cu(II) nanoparticles (NPs) concentrations on wound closure and tissue regeneration in a diabetic rat model. Streptozotocin-induced diabetic Sprague-Dawley rats were used to evaluate the in vivo efficacy of NPs. Characterization involved digital photography for wound closure quantification, histopathological analysis for tissue repair assessment, and statistical methods for data interpretation. Our findings indicated that the 1% Cu nanoparticle (NP) -embedded hydrogel significantly improved wound healing, including enhanced reepithelialization, collagen deposition, neovascularization, granulation tissue formation, and fibroblast activation, while also reducing inflammation. The 10% Cu NP formulation did not demonstrate the same level of efficacy, suggesting a concentration-dependent therapeutic window for copper ion release. This novel NP hydrogel showcases the potential of copper-based NPs in diabetic wound management, offering a cost-effective and promising approach for treating a global health issue.
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A comprehensive review on MXene nanostructures for biosensing, imaging, and therapeutic systems
(Elsevier BV, 2026-02)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Because of their exceptional electrical, mechanical, dimensional, chemical, and magnetic characteristics, MXenes have attracted an abundance of interest in scholarly study lately. According to recent developments and discoveries, MXene, a multilayered compound with a two-dimensional (2D) framework, has a lot greater promise for use in bioengineering and medical research than other nanosystems. These uses encompass medical procedures, administering medications, biosensor technologies, incorporation, antimicrobial agents, and biological imaging. MXenes are very attractive prospects for therapeutic, diagnostic, and theranostic use because of their distinctive features, which include their substantial conductivity to electricity, magnetic luminescence, wide extent of coverage, excellent biocompatibility, and low toxicological profile. Modifications to the MXene surfaces are biocompatible and serve a variety of purposes, such as directing ligands to certain locations for preferred aggregation, which makes them suitable for use in particular applications. A description of the properties, changes, and synthesis techniques of MXene nanostructures is presented in this work. The practical applications of MXene-derived nanostructures in biomedical fields are also thoroughly evaluated in this study, with an emphasis on implants, biosensing, biological imaging, antibacterial activities, and versatile therapeutic systems. The potential opportunities and difficulties related to the use of MXenes throughout the field of biological medicine are also covered in this paper.
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Mxenes as a versatile nanoplatform: Synthesis and emerging biomedical applications
(Elsevier BV, 2025-09-25)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Recently, MXenes have garnered significant attention in academic research due to their remarkable structural, electrical, magnetic, optical, mechanical, and chemical properties. New advancements and emerging findings indicate that MXene, classified as a two-dimensional (2D) layered material, exhibits significantly more potential in the field of biomedicine and biotechnology compared to existing nanosystems. These applications include acting as antibacterial agents, biosensor systems, the delivery and loading of drugs, bioimaging, and therapeutic interventions. The unique characteristics of MXenes, such as their significant electrical conductivity, large surface area, low toxicity, magnetism, luminescence, and high biocompatibility, make them highly promising candidates for diagnostic, therapeutic, and theranostic applications. Surface modifications of MXenes exhibit biocompatibility and have multifunctional functions, including the ability to direct ligands towards specific spots for preferential aggregation, hence enabling their utilization in specialized applications. This paper provides an overview of the characteristics, modifications, and synthesis methods of MXene nanomaterials. The present article also delivers a comprehensive assessment of the practical uses of MXene-based nanomaterials in biomedicine, with a particular focus on biosensing, bioimaging, antibacterial effects, implants, and multifunctional therapeutic platforms. This paper also presents a discussion of the future prospects and challenges associated with the applications of MXenes in the biomedicine field.
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MXene-based materials for enhanced water quality: Advances in remediation strategies
(Elsevier BV, 2025-02-01)
Ali Mohammad Amani
;
Milad Abbasi
;
Atena Najdian
;
Farzaneh Mohamadpour
;
Seyed Reza Kasaee
Two-dimensional MXenes are promising candidates for water treatment because of their large surface area (e.g., exceeding 1000 m²/g for certain structures), high electrical conductivity (e.g., >1000 S/m), hydrophilicity, and chemical stability. Their strong sorption selectivity and effective reduction capacity, exemplified by heavy metal adsorption efficiencies exceeding 95 % in several studies, coupled with facile surface modification, make them suitable for removing diverse contaminants. Applications include the removal of heavy metals (e.g., achieving >90 % removal of Pb(II)), dye removal (e.g., demonstrating >80 % removal of methylene blue), and radioactive waste elimination. Furthermore, 3D MXene architecture exhibit enhanced performance in antibacterial activities (e.g., against bacteria), desalination rejection percentage, and photocatalytic degradation of organic contaminants. However, several challenges have remained, which necessitate further investigation into toxicity (e.g., assessing effects on aquatic organisms), scalability, and cost-effectiveness of large-scale production. This review summarizes recent advancements in 3D MXene-based functional materials for wastewater treatment and water remediation, critically analyzing their both potential and limitations.
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Synthesis of Fe3O4 MIL-101-OH/Chitosan for adsorption and release of doxorubicin
(Elsevier BV, 2025-01-01)
Iman Najafipour
;
Nafiseh Emami
;
Pegah Sadeh
;
Adonis Amoli
;
Sareh Mosleh-Shirazi
This study reports the synthesis and characterization of a magnetic composite metal-organic framework, The Fe3O4@MIL-101-OH/Chitosan nanocomposite was used for the first time to adsorb and release the drug doxorubicin (DOX). The nanocomposite was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The characterization results showed that the synthesized nanocomposite has a crystalline structure and good magnetic properties. Also, this nanocomposite has a high specific surface area (610.36 m2/g). In this article, the effect of pH, contact time, and drug concentration on DOX adsorption were investigated, and the results showed that at optimal conditions, pH = 8, contact time = 90 min, and drug concentration is 350 ppm, the adsorption capacity of MIL-101-OH/Chitosan and Fe3O4@MIL-101-OH/Chitosan are equal to 185 and 174.3 mg/g. The adsorption data follows pseudo-second-order kinetic and Langmuir isotherm models. The adsorption was physical and reversible. As a result, drug release was checked. The Fe3O4@MIL-101-OH/Chitosan exhibited a controlled release over the period of 84 h at pH 5 and reached 80 % of the DOX release rate after 60 h. In conclusion, the Fe3O4@MIL-101-OH/Chitosan composite has great potential as a drug delivery system as a result of its high adsorption capacity and magnetic properties. This research provides a promising approach for the development of novel drug delivery systems for cancer therapy.
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Exploring the functionality of MXenes as promising versatile antimicrobial agents and their novel applications
(Elsevier BV, 2024-12)
Ali Mohammad Amani
;
Ali Rahbar
;
Ehsan Vafa
;
Lobat Tayebi
;
Milad Abbasi
Given the increasing drug resistance exhibited by viruses, fungi, and bacteria, there is an urgent demand for the creation and utilization of novel structures that possess exceptional efficacy. MXenes have demonstrated potent bactericidal activity, effectively suppressing the growth of gram- negative and gram- positive bacterial strains. Their mode of antimicrobial action primarily involves disrupting the bacterial cell membrane. Additionally, MXenes exhibit antifungal properties, holding promise for applications in combating fungal infections. Emerging studies suggest that certain MXenes can also possess antiviral properties, impacting both enveloped and non-enveloped viruses. Researchers are exploring their use in wound healing, where they can prevent infections and accelerate the healing process. Furthermore, MXenes can be integrated into coatings, composites, and surfaces, finding applications in medical devices, textiles, and food packaging for antimicrobial purposes. The potential for MXenes to be employed in photothermal and photodynamic therapy adds another layer to their multifaceted antimicrobial capabilities. When activated by light, MXenes can target and eliminate cancer cells or pathogens. Research in this domain is progressing, with the prospect of novel materials and strategies to combat bacterial, fungal, and viral infections. This article discussed recent progress in the field of antibacterial, anti-fungal, and antiviral properties of MXenes and MXene-derived materials. Furthermore, their biocompatibility and toxicity issues, as well as the challenges and future opportunities of MXenes in the field of antimicrobial applications, are discussed. Overall, MXenes hold considerable promise for addressing the pressing global concern of antimicrobial resistance and opening new avenues for advanced medical technologies.
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Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species
(Springer Science and Business Media LLC, 2024-03-11)
Sedigheh Azadi
;
Esmat Azizipour
;
Ali Mohammad Amani
;
Ahmad Vaez
;
Zahra Zareshahrabadi
The antifungal efficacy and cytotoxicity of a novel nano-antifungal agent, the Fe3O4@SiO2/Schiff-base complex of Cu(II) magnetic nanoparticles (MNPs), have been assessed for targeting drug-resistant Candida species. Due to the rising issue of fungal infections, especially candidiasis, and resistance to traditional antifungals, there is an urgent need for new therapeutic strategies. Utilizing Schiff-base ligands known for their broad-spectrum antimicrobial activity, the Fe3O4@SiO2/Schiff-base/Cu(II) MNPs have been synthesized. The Fe3O4@SiO2/Schiff-base/Cu(II) MNPs was characterized by Fourier Transform-Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), Energy-dispersive X-ray (EDX), Vibrating Sample Magnetometer (VSM), and Thermogravimetric analysis (TGA), demonstrating successful synthesis. The antifungal potential was evaluated against six Candida species (C. dubliniensis, C. krusei, C. tropicalis, C. parapsilosis, C. glabrata, and C. albicans) using the broth microdilution method. The results indicated strong antifungal activity in the range of 8–64 μg/mL with the lowest MIC (8 μg/mL) observed against C. parapsilosis. The result showed the MIC of 32 μg/mL against C. albicans as the most common infection source. The antifungal mechanism is likely due to the disruption of the fungal cell wall and membrane, along with increased reactive oxygen species (ROS) generation leading to cell death. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay for cytotoxicity on mouse L929 fibroblastic cells suggested low toxicity and even enhanced cell proliferation at certain concentrations. This study demonstrates the promise of Fe3O4@SiO2/Schiff-base/Cu(II) MNPs as a potent antifungal agent with potential applications in the treatment of life-threatening fungal infections, healthcare-associated infections, and beyond.

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