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Author: search.filters.author.SIMANCAS RACINES, DANIEL ALEJANDROSubject: search.filters.subject.Healthcare

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    Item type:Publication,
    Next-Generation sequencing in a Native American patient with sea-blue histiocytosis: A case report and genomic analysis
    (Medwave Estudios Limitada, 2025-08-08)
    ZAMBRANO ESPINOSA, ANA KARINA  
    ;
    RUIZ POZO, VIVIANA ALEJANDRA  
    ;
    Mateo Antonio Rodríguez
    ;
    Paz Cruz Elius Andrés  
    ;
    CADENA ULLAURI, SANTIAGO ANDRE  
    This study presents a case of a 25-year-old Native American woman from Otavalo, Ecuador, diagnosed with sea-blue histiocytosis and myelodysplastic syndrome. Bone marrow aspiration revealed sea-blue histiocytes, and next-generation sequencing identified a likely pathogenic stop-gain mutation in the gene, associated with myelodysplastic syndrome. Additionally, variants of uncertain significance were found in the and genes. Ancestral analysis showed a predominantly Native American composition, suggesting a potential genetic predisposition specific to Andean communities. The report underscores the importance of understanding genetic and ancestral backgrounds in diagnosing and managing hematological disorders.
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    Healthcare attitudes toward depression in Latin America: a latent class analysis from Argentina, Chile, Ecuador, Peru, and Venezuela using the Spanish-validated revised depression attitude questionnaire (SR-DAQ)
    (Springer Science and Business Media LLC, 2025-10-01)
    Marco Faytong-Haro
    ;
    Genesis Camacho-Leon
    ;
    Robert Araujo-Contreras
    ;
    Stephanie Gallegos
    ;
    Hans Mautong
    Background: Depression significantly impacts health systems worldwide, particularly in Latin America, where cultural stigmatization and misconceptions about mental health deter individuals from seeking help. Healthcare professionals’ attitudes toward depression may affect its prevention, diagnosis and treatment. Objective: To categorize Latin American healthcare professionals’ attitudes towards diagnosis and management of depression in subgroups using the Spanish-validated Revised Depression Attitude Questionnaire (SR-DAQ). Methods: A cross-sectional study surveyed 2,409 professionals using SR-DAQ from 2019 to 2022. Latent class analysis and multinomial logistic regression were used to identify attitude classes and explore demographic influences. Results: Among our sample, four attitude classes were identified: Depression Skeptics (21%), Depression Cautious (33%), Depression Neutrals (18%), and Depression Advocates (28%). Gender and medical subspecialty significantly influenced class membership, with females and mental health specialists more likely to be part of the Advocates. Conclusion: The study reveals varied attitudes towards depression among Latin American healthcare professionals, suggesting the need for tailored public health strategies to enhance effective depression care and management.
    Scopus© Citations 2