State of Art of Cancer Pharmacogenomics in Latin American Populations

Andrés López-Cortés; Santiago Guerrero; María Redal; Angel Alvarado; Luis Quiñones

doi:10.3390/ijms18060639

State of Art of Cancer Pharmacogenomics in Latin American Populations

Journal

International Journal of Molecular Sciences

ISSN

1422-0067

Date Issued

2017-05-23

Author(s)

Andrés López-Cortés

Facultad de Ciencias de la Salud Eugenio Espejo

Santiago Guerrero

María Redal

Angel Alvarado

Luis Quiñones

DOI

10.3390/ijms18060639

URL

https://cris.ute.edu.ec/handle/123456789/984

Abstract

Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.