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    Item type:Publication,
    Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents
    (Springer Science and Business Media LLC, 2025-01-31)
    ZUÑIGA MIRANDA, JOHANA JANINA  
    ;
    GONZALEZ PASTOR, REBECA EUGENIA  
    ;
    Saskya E. Carrera Pacheco
    ;
    Cristina Rodríguez-Pólit
    ;
    Carlos Barba-Ostria
    Schiff bases are organic compounds recognized for their biological activities, including antiviral, antibacterial, antifungal, and anticancer properties, making them promising candidates in medicinal chemistry. In this studio, a series of Schiff bases derived from 4-aminoantipyrine and substituted cinnamaldehydes were evaluated in vitro against liver (HepG2) and thyroid (THJ29T) cancer cells, Gram-positive and Gram-negative multidrug-resistant bacteria, and biofilm-forming pathogens. Six compounds demonstrated anticancer activity, though some exhibited toxicity to non-tumor cells. Compounds showed notable anticancer potential, while also exhibited strong antibacterial effects, with being the most effective against multidrug-resistant bacteria strains. These Schiff bases also inhibit biofilm formation, suggesting their potential for treating biofilm-related infections. analyses of their ADME properties, global reactivity descriptors, and binding affinities corroborated these findings. The Schiff base has a strong binding affinity for DNA gyrase and vitamin D receptor, suggesting potential mechanisms for its antibacterial and anticancer activities.
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    An eco-friendly synthesis of titanium oxide nanoparticles mediated from Syringodium isoetifolium and evaluate its biological activity and photocatalytic dye degradation
    (Elsevier BV, 2024-03)
    Velmani Sundar
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Mani Sivakumar
    ;
    Santhosh Chinnaraj
    ;
    Vino Palani
    In this present investigation, titanium oxide nanoparticles (TiO2 NPs) were synthesized from seagrass aqueous extract of Syringodium isoetifolium. The TiO2 NPs were characterized by various spectroscopy techniques. The TiO2 NPs have a spherical shape, according to FE-SEM images. Then the TiO2 NPs exhibit antioxidant activities through DPPH (1, 1-diphenyl 2-picrylhyorazyl), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) ABTS, and metal chelating assay. The DPPH and ABTS were better antioxidant activities compared to standard values. The investigation of antibacterial activity was against various microorganism, Staphylococcus epidermidis of the prime zone of inhibition was 18.6 mm and the anticancer activity against a human breast cancer cell line indicated excellent inhibition of cell viability; the IC50 value of 60 µg/mL shows dose-dependent specificity. Further, the TiO2 NPs were examined the methylene blue and methyl orange of dye degradation. The percentage of degradation by the TiO2 NPs was found to be higher in methylene blue (83 %) than methyl orange (58 %) for S. isoetifolium with marine macro algae extract after 120 min of visible light irradiation. The green synthesis of TiO2 NPs emphases to be cost effective and eco-friendly with antimicrobial and anti-cancer effects against breast cancer cell lines.