CRIS

Permanent URI for this communityhttps://cris.ute.edu.ec/handle/123456789/1

Browse

Settings

Language: search.filters.language.EnglishSubject: search.filters.subject.heavy metals

Search Results

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Heavy Metal-Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective
    (MDPI AG, 2025-11-27)
    Claudia Reytor-González
    ;
    LEYVA RICARDO, SONIA EMILIA  
    ;
    Yasniel Sánchez Suárez
    ;
    Vianey Ariadna Burboa Charis
    ;
    Emilia Jiménez-Flores
    Heavy metal contamination in agricultural soils has emerged as a critical environmental and public health issue associated with increased gastric cancer incidence worldwide. Among the most concerning pollutants are cadmium, arsenic, and lead, which persist in the environment and enter the human body primarily through the soil–plant–food chain. This review integrates environmental, molecular, and epidemiological evidence to explain how these metals alter gastric mucosal biology and promote carcinogenesis. Mechanistically, cadmium, arsenic, and lead trigger oxidative stress, mitochondrial dysfunction, DNA damage, and epigenetic reprogramming, resulting in genomic instability, resistance to programmed cell death, and the transformation of epithelial cells into invasive phenotypes. These molecular disruptions interact with Helicobacter pylori infection, microbial imbalance, chronic inflammation, and hypoxia-driven remodeling of the gastric stroma, all of which enhance angiogenesis and tumor progression. Advanced experimental platforms, such as gastric organoids, immune co-cultures, and humanized animal models, are improving the understanding of these complex interactions. Adopting a One Health perspective reveals the continuity between environmental contamination, agricultural production, and human disease, underscoring the importance of integrative monitoring systems that combine soil and crop analysis with molecular biomarkers in exposed populations. Strengthening this interdisciplinary approach is essential to design preventive strategies, guide remediation policies, and protect human, animals, and environmental health.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Computational stability analysis of sport structures: Importance of MEMS for testing athlete performance
    (2025-01-10)
    Liang Xia
    ;
    HABIBI, MOSTAFA  
    ;
    Qinyang Li
    The cultivation of cocoa (Theobroma cacao L.) is one of the most important crops in Ecuador. However, the presence of heavy metals in the soil is of concern, with cadmium (Cd) being one of the most worrisome contaminants, and its presence in the kernel has become a limiting factor for export. This work aimed to determine the capacity of arboreal plants to extract Cd. Therefore, nine species were evaluated in sandy-frank soil with 2.4 % MO and a pH of 6.2, contaminated with 3 mg/kg of Cd. The variables evaluated were dry matter, soil and rhizosphere pH, Cd concentration and content, and translocation factor. The weed species that showed high adaptability and absorbed significant amounts of Cd were Pseudelephantopus spiralis, Oplismenus burmannii, Geophila macropoda, and Ipomoea grandifolia. In contrast, Commelina difusa, Pseudelephantopus spiralis, Cissus verticillata, Epipomoea verticillata, and Epipremnum aureum functioned as metal stabilizers, indicating that they can be considered as hyperaccumulators of Cd, facilitating its safe removal from the soil.