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Language: search.filters.language.EnglishSubject: search.filters.subject.Regenerative medicine

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    Optimizing fish skin scaffolds for regenerative medicine: A comparative study of physical and chemical decellularization techniques
    (Elsevier BV, 2026-05)
    Esmat Azizipour
    ;
    Hengameh Honarkar
    ;
    Reza Yarahmadi
    ;
    Ahmad Vaez
    ;
    Mehdi Kian
    Fish skin scaffolds have great potential as biocompatible materials for skin regeneration, as they contain high levels of collagen and are structurally similar to the mammalian extracellular matrix (ECM). In this study, we compared the efficiency of physical decellularization with chemical decellularization using sodium dodecyl sulphate (SDS), sodium lauryl ether sulfate (SLES), and Triton X-100 at two concentrations (0.5% and 1%) and two time intervals (6 and 12 h). The decellularization efficiency and quality of scaffolds were assessed via histological observations, glycosaminoglycan (GAG) content, MTT assay to evaluate cytocompatibility, scaffold degradation rate, and scanning electron microscopy (SEM) observations. Silicone membrane physical decellularization preserves the integrity of the ECM, retains higher levels of GAG (1.5 µg/mm³) and higher levels of fibroblast viability (p < 0.001) and demonstrates limited degradation (< 20% on day 14) compared to chemical decellularization. Chemical decellularization caused some breakdown of the ECM, particularly treatments at 1%-12h, and was able to retain lower levels of GAG (0.5–0.9 µg/mm³) while degrading more (up to 150%). SEM shows the scaffolds from the physical decellularization treatment had a clearer fibrous structure compared to the variable porosity of the chemical treatment.
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    MXenes in tissue engineering and regenerative medicine: Advances, challenges, and future perspectives
    (Elsevier BV, 2025-10)
    Ali Mohammad Amani
    ;
    Lobat Tayebi
    ;
    Ehsan Vafa
    ;
    Mohammad Javad Azizli
    ;
    Milad Abbasi
    The appealing charm of two-dimensional (2D) materials has sparked a wave of innovation across diverse scientific domains, particularly in the realm of biomedical and therapeutic applications. Among these remarkable materials, MXenes stand out as transition metal nitrides and carbides endowed with extraordinary properties. Boasting low toxicity, expansive surface area, antibacterial prowess, biocompatibility, hydrophilicity, and impressive electrical conductivity, MXenes hold immense promise for a myriad of biomedical applications from bioimaging to cancer therapy and beyond. Despite their vast potential, challenges persist in ensuring controlled drug release, stability in physiological milieus, and biodegradability. By harnessing the transformative power of nanomedicine, meticulously crafted MXene ultra-thin nanosheets emerge as versatile inorganic nanosystems primed for diverse biomedical roles. Positioned as optimal candidates for regenerative medicine and tissue engineering, MXenes mark a new age of healthcare innovation. This article delves into the latest strides made in leveraging 2D MXenes for cutting-edge regenerative medicine and tissue engineering applications while shedding light on the formidable obstacles and promising future vistas awaiting exploration with these extraordinary materials.