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Advances in green synthesis of nanoparticles for biomedical applications: Antimicrobial, antiviral, and cancer therapies
(Elsevier BV, 2026-03)
HESAM, KAMYAB
;
Elham Khalili
;
Tayebeh Khademi
;
Ali Yuzir
;
Mohammad Mahdi Taheri
Green synthesis of nanoparticles (NPs) has garnered a considerable amount of attention lately due to its low production expenses, simplicity of manufacturing, safety, and environmental friendliness. It is a dependable method for creating a variety of nanostructures from fungal, plant, and bacterial extracts as well as hybrid materials, including metal salts. A viable and sustainable substitute for traditional synthesis methods is the green synthesis of NPs. According to recent research, NPs have very promising antiviral and antimicrobial capabilities. This article highlights the progress made in the green method for manufacturing NPs utilizing natural substances, including fruit juices, plant extracts, and other pertinent sources. A thorough understanding of these NPs' anticancer, antiviral, and antimicrobial abilities was presented. Numerous opportunities are presented by these NPs to combat potentially fatal viral and other antimicrobial diseases. This review provides readers with a grasp of the latest data and a variety of tactics for designing and developing advanced green nanomaterials using a more environmentally friendly approach. A summary is provided of the present difficulties, critical analysis, and prospects for the green synthesis of NPs as well as the potential for their innovative and successful investigation for biomedical applications.
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Emerging nanoparticle-based strategies for advanced cancer imaging and diagnosis
(Elsevier BV, 2025-10-15)
HESAM, KAMYAB
;
Elham Khalili
;
Ali Yuzir
;
Mohammad Mahdi Taheri
;
ZAMBRANO ESPINOSA, ANA KARINA
The urgent necessity for early disease diagnosis and detection continues to drive innovation in imaging techniques and contrast agents. Nanoparticle-based bioimaging offers significant potential to enhance therapeutics, treatment management, and cancer diagnostics. In both clinical practice and biomedical research, nanoparticles (NPs) can serve as labeled carriers or biomarkers for tracking immunotherapy responses, contrast-enhancing agents for improved imaging, or signal amplifiers to increase specificity and sensitivity in the visualization of cellular and molecular mechanisms in vivo. The development of advanced imaging probes with controlled biodistribution, heightened sensitivity, improved contrast, multifunctionality, and enhanced temporal and spatial resolution is made possible by the unique chemical, magnetic, and optical properties of nanomaterials. These probes are particularly beneficial, to multi-modal imaging techniques such as single-photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasound (US). Finally, these characteristics contribute to clinical benefits, including personalized medicine, real-time monitoring of disease progression, AI-based design of nanoparticles (NPs) and earlier detection, addressing current limitations in oncologic imaging. This review highlights promising nanoparticle-based imaging strategies, including radiolabeled nanoparticles for dual/multimodal cancer imaging, bio-conjugated quantum dots (QDs) for in vivo and in vitro diagnosis and imaging, green-synthesized nanoparticles for cancer diagnostics, nanoparticle-enabled molecular imaging strategies for monitoring immunotherapy responses, MXene-based imaging systems, and nanoparticle-assisted image-guided therapies. Collectively, these imaging technologies present novel tools to resolve biological challenges, enhance the effectiveness of cancer treatments, and drive clinical translation, which ultimately improve patient outcomes and care.
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Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives
(Elsevier BV, 2025-12-01)
Kaakarlu Shivakumar Vinanthi Rajalakshmi
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Balamuralikrishnan Balasubramanian
;
Hemanth Hinnakki
;
Arun Meyyazhagan
;
Wen-Chao Liu
Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.
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Navigating green synthesized metal-based nanoparticles as anti-inflammatory agent – Comprehensive review
(Elsevier BV, 2025-02-10)
Sumanth Hegde
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Balamuralikrishnan Balasubramanian
;
Ridhika Paul
;
M Jayalakshmi
;
Aatika Nizam
The biosynthesis of nanomaterials is a vast and expanding field of study due to their applications in a variety of fields, particularly the pharmaceutical and biomedical fields. Various synthetic routes, including physical and chemical methods, have been developed in order to generate metal nanoparticles (NPs) with definite shapes and sizes. In this review, focused on the recent advancements in the green synthetic methods for the generation of silver, zinc and copper NPs with simple and eco-friendly approaches and the potential of the biosynthesized metal and metal oxide NPs as alternative and therapeutic agent for the treatment of inflammatory diseases. Inflammation is a body's own defense mechanism that can become chronic inflammation affecting healthy cells. Owning to the size-based advantages of NPs which can mitigate in theses medical conditions and serve as anti-inflammatory drugs. The factors influencing their physicochemical properties, toxicity, biocompatibility and mode of action to formulate an effective nanomedicine in the treatment of inflammation.

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