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Alginate hydrogel film reinforced with Fe3O4@SiO2/Schiff-base/Cu(II) nanoparticles in promoting diabetic wound healing
(Elsevier BV, 2026-04)
Sedigheh Azadi
;
Alireza Abbaspour
;
Seyed Reza Kasaee
;
Farhad Koohpeyma
;
Esmat Azizipour
In the quest to enhance diabetic wound healing, we synthesized Fe3O4@SiO2/Schiff-base complex of Cu(II) magnetic nanoparticles (MNPs) embedded in sodium alginate hydrogel. This study analyzed the effects of 1% and 10% Cu(II) nanoparticles (NPs) concentrations on wound closure and tissue regeneration in a diabetic rat model. Streptozotocin-induced diabetic Sprague-Dawley rats were used to evaluate the in vivo efficacy of NPs. Characterization involved digital photography for wound closure quantification, histopathological analysis for tissue repair assessment, and statistical methods for data interpretation. Our findings indicated that the 1% Cu nanoparticle (NP) -embedded hydrogel significantly improved wound healing, including enhanced reepithelialization, collagen deposition, neovascularization, granulation tissue formation, and fibroblast activation, while also reducing inflammation. The 10% Cu NP formulation did not demonstrate the same level of efficacy, suggesting a concentration-dependent therapeutic window for copper ion release. This novel NP hydrogel showcases the potential of copper-based NPs in diabetic wound management, offering a cost-effective and promising approach for treating a global health issue.
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A potentially fruitful path toward a cleaner and safer environment: MXenes uses in environmental remediation
(Elsevier BV, 2025-06-01)
Ali Mohammad Amani
;
Milad Abbasi
;
Atena Najdian
;
Farzaneh Mohamadpour
;
Seyed Reza Kasaee
The rapid industrialization of the world has resulted in severe environmental pollution, necessitating the development of new materials such as pollution remediation. Two-dimensional (2D) MXenes have emerged as a promising family of materials due to their unique physicochemical properties, making them ideal for environmental remediation. The article sheds light on the new opportunities of MXenes in the removal of organic and inorganic contaminants, including organic dyes, pharmaceuticals, heavy metals, radionuclides, and gas pollutants. MXenes also show excellent performance in photocatalytic degradation, adsorption, and microbial inactivation with environmental safety. Moreover, their application in recovering valuable elements from waste streams is also being explored. While these advances are promising, challenges remain in surface chemistry, semiconducting behavior, interfacial effects, and large-scale synthesis. This review highlights the tremendous potential of MXenes in environmental remediation while also outlining the key challenges that need to be resolved to fully realize MXenes capabilities. By providing this comprehensive survey of MXene-based technologies, the paper stimulates further research and innovation in this rapidly evolving field.
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MXene-based materials for enhanced water quality: Advances in remediation strategies
(Elsevier BV, 2025-02-01)
Ali Mohammad Amani
;
Milad Abbasi
;
Atena Najdian
;
Farzaneh Mohamadpour
;
Seyed Reza Kasaee
Two-dimensional MXenes are promising candidates for water treatment because of their large surface area (e.g., exceeding 1000 m²/g for certain structures), high electrical conductivity (e.g., >1000 S/m), hydrophilicity, and chemical stability. Their strong sorption selectivity and effective reduction capacity, exemplified by heavy metal adsorption efficiencies exceeding 95 % in several studies, coupled with facile surface modification, make them suitable for removing diverse contaminants. Applications include the removal of heavy metals (e.g., achieving >90 % removal of Pb(II)), dye removal (e.g., demonstrating >80 % removal of methylene blue), and radioactive waste elimination. Furthermore, 3D MXene architecture exhibit enhanced performance in antibacterial activities (e.g., against bacteria), desalination rejection percentage, and photocatalytic degradation of organic contaminants. However, several challenges have remained, which necessitate further investigation into toxicity (e.g., assessing effects on aquatic organisms), scalability, and cost-effectiveness of large-scale production. This review summarizes recent advancements in 3D MXene-based functional materials for wastewater treatment and water remediation, critically analyzing their both potential and limitations.
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Synthesis of Fe3O4 MIL-101-OH/Chitosan for adsorption and release of doxorubicin
(Elsevier BV, 2025-01-01)
Iman Najafipour
;
Nafiseh Emami
;
Pegah Sadeh
;
Adonis Amoli
;
Sareh Mosleh-Shirazi
This study reports the synthesis and characterization of a magnetic composite metal-organic framework, The Fe3O4@MIL-101-OH/Chitosan nanocomposite was used for the first time to adsorb and release the drug doxorubicin (DOX). The nanocomposite was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The characterization results showed that the synthesized nanocomposite has a crystalline structure and good magnetic properties. Also, this nanocomposite has a high specific surface area (610.36 m2/g). In this article, the effect of pH, contact time, and drug concentration on DOX adsorption were investigated, and the results showed that at optimal conditions, pH = 8, contact time = 90 min, and drug concentration is 350 ppm, the adsorption capacity of MIL-101-OH/Chitosan and Fe3O4@MIL-101-OH/Chitosan are equal to 185 and 174.3 mg/g. The adsorption data follows pseudo-second-order kinetic and Langmuir isotherm models. The adsorption was physical and reversible. As a result, drug release was checked. The Fe3O4@MIL-101-OH/Chitosan exhibited a controlled release over the period of 84 h at pH 5 and reached 80 % of the DOX release rate after 60 h. In conclusion, the Fe3O4@MIL-101-OH/Chitosan composite has great potential as a drug delivery system as a result of its high adsorption capacity and magnetic properties. This research provides a promising approach for the development of novel drug delivery systems for cancer therapy.
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Exploring the functionality of MXenes as promising versatile antimicrobial agents and their novel applications
(Elsevier BV, 2024-12)
Ali Mohammad Amani
;
Ali Rahbar
;
Ehsan Vafa
;
Lobat Tayebi
;
Milad Abbasi
Given the increasing drug resistance exhibited by viruses, fungi, and bacteria, there is an urgent demand for the creation and utilization of novel structures that possess exceptional efficacy. MXenes have demonstrated potent bactericidal activity, effectively suppressing the growth of gram- negative and gram- positive bacterial strains. Their mode of antimicrobial action primarily involves disrupting the bacterial cell membrane. Additionally, MXenes exhibit antifungal properties, holding promise for applications in combating fungal infections. Emerging studies suggest that certain MXenes can also possess antiviral properties, impacting both enveloped and non-enveloped viruses. Researchers are exploring their use in wound healing, where they can prevent infections and accelerate the healing process. Furthermore, MXenes can be integrated into coatings, composites, and surfaces, finding applications in medical devices, textiles, and food packaging for antimicrobial purposes. The potential for MXenes to be employed in photothermal and photodynamic therapy adds another layer to their multifaceted antimicrobial capabilities. When activated by light, MXenes can target and eliminate cancer cells or pathogens. Research in this domain is progressing, with the prospect of novel materials and strategies to combat bacterial, fungal, and viral infections. This article discussed recent progress in the field of antibacterial, anti-fungal, and antiviral properties of MXenes and MXene-derived materials. Furthermore, their biocompatibility and toxicity issues, as well as the challenges and future opportunities of MXenes in the field of antimicrobial applications, are discussed. Overall, MXenes hold considerable promise for addressing the pressing global concern of antimicrobial resistance and opening new avenues for advanced medical technologies.
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Bromelain-loaded silver nanoparticles: Formulation, characterization and biological activity
(Elsevier BV, 2024-03)
Farshid Gheisari
;
Seyed Reza Kasaee
;
Pardis Mohamadian
;
Shreeshivadasan Chelliapan
;
Razieh Gholizadeh
Bromelain (BL), a type of proteolytic enzymes from Ananas comosus (pineapple), has a variety of therapeutic potentials; nevertheless, its low bioavailability has restricted the clinical applications. The main aim of the current research was to develop a green synthesized Ag-BL nanoparticles via a cost-effective route to improve the physicochemical and antimicrobial characteristics as a novel agent for medical applications. In the present study, Bromelain was loaded on the silver nanoparticle surface via covalent bonds through green synthesis method. The physicochemical properties of Ag-BL nanoparticles characterized by following a detailed analysis over scanning electron microscopy, zeta potential, ultraviolet–visible absorption spectroscopy, transmission electron microscopy, fourier transform infrared spectroscopy, and X-ray diffraction studies. The antifungal and antibacterial activity were investigated by the Clinical and Laboratory Standards Institute methods and the results were compared with Ag NPs and plain bromelain. The cytotoxicity of Ag-BL nanoparticles was investigated by MTT assay. The TEM and XRD techniques revealed the successful biosynthesis of Ag-BL nanoparticles in spherical shape with the mean size of 7 to 24 nm and FTIR analysis pattern proved the attachments of bromelain and Ag nanoparticles in the fabricated nanostructure. The negative zeta value of the Ag-BL nanoparticles (−50 to –32 mV) indicates their high stability in the suspension. The Ag-BL nanoparticles demonstrated significant antimicrobial activity against various types of fungi and bacteria strains with a MIC range of 4–32 and 4–64 μg/mL, respectively. The MTT assay analysis determined the acceptable cell safety of Ag-BL nanoparticles. Generally, the results confirmed that Ag-BL nanoparticles could develop a new insight to produce antimicrobial products for biomedical applications.

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