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Revolutionizing corrosion protection: MXenes as next-generation materials for sustainable and high-performance solutions
(Elsevier BV, 2026-01)
Ehsan Vafa
;
Reza Bazarganlari
;
Hengameh Honarkar
;
Lobat Tayebi
;
Peyman Asadi
Corrosion is a pervasive problem that has spurred the development of innovative materials and technologies aimed at mitigating its impact across industries worldwide. MXenes, a rapidly growing family of 2D transition metal carbides, nitrides, and carbonitrides, have emerged as promising candidates for corrosion protection due to their exceptional properties, including high surface area, mechanical strength, electrical conductivity, and tunable surface chemistry. This review highlights the diverse applications of MXenes in corrosion science, particularly their use as corrosion-resistant coatings, inhibitors, and sensors. We emphasize the key properties, such as barrier performance, electrochemical activity, and the ability to form protective layers, that make MXenes highly effective in combating corrosion. Specific applications, including their role in composite coatings, self-healing systems, and multifunctional inhibitors in both acidic and alkaline environments, are discussed. Additionally, the potential in electrochemical corrosion monitoring and the mitigation of specific corrosion types, such as pitting and high-temperature corrosion, were explored. While these applications demonstrate promising performance, further research is needed to address challenges related to stability, scalability, and environmental impact. This review provides a comprehensive overview of current MXene-based corrosion protection technologies, aiming to inspire further innovation and advance the practical application of MXenes in addressing one of the most significant challenges in materials science today.
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A comprehensive review on MXene nanostructures for biosensing, imaging, and therapeutic systems
(Elsevier BV, 2026-02)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Because of their exceptional electrical, mechanical, dimensional, chemical, and magnetic characteristics, MXenes have attracted an abundance of interest in scholarly study lately. According to recent developments and discoveries, MXene, a multilayered compound with a two-dimensional (2D) framework, has a lot greater promise for use in bioengineering and medical research than other nanosystems. These uses encompass medical procedures, administering medications, biosensor technologies, incorporation, antimicrobial agents, and biological imaging. MXenes are very attractive prospects for therapeutic, diagnostic, and theranostic use because of their distinctive features, which include their substantial conductivity to electricity, magnetic luminescence, wide extent of coverage, excellent biocompatibility, and low toxicological profile. Modifications to the MXene surfaces are biocompatible and serve a variety of purposes, such as directing ligands to certain locations for preferred aggregation, which makes them suitable for use in particular applications. A description of the properties, changes, and synthesis techniques of MXene nanostructures is presented in this work. The practical applications of MXene-derived nanostructures in biomedical fields are also thoroughly evaluated in this study, with an emphasis on implants, biosensing, biological imaging, antibacterial activities, and versatile therapeutic systems. The potential opportunities and difficulties related to the use of MXenes throughout the field of biological medicine are also covered in this paper.
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MXenes in tissue engineering and regenerative medicine: Advances, challenges, and future perspectives
(Elsevier BV, 2025-10)
Ali Mohammad Amani
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Lobat Tayebi
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Ehsan Vafa
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Mohammad Javad Azizli
;
Milad Abbasi
The appealing charm of two-dimensional (2D) materials has sparked a wave of innovation across diverse scientific domains, particularly in the realm of biomedical and therapeutic applications. Among these remarkable materials, MXenes stand out as transition metal nitrides and carbides endowed with extraordinary properties. Boasting low toxicity, expansive surface area, antibacterial prowess, biocompatibility, hydrophilicity, and impressive electrical conductivity, MXenes hold immense promise for a myriad of biomedical applications from bioimaging to cancer therapy and beyond. Despite their vast potential, challenges persist in ensuring controlled drug release, stability in physiological milieus, and biodegradability. By harnessing the transformative power of nanomedicine, meticulously crafted MXene ultra-thin nanosheets emerge as versatile inorganic nanosystems primed for diverse biomedical roles. Positioned as optimal candidates for regenerative medicine and tissue engineering, MXenes mark a new age of healthcare innovation. This article delves into the latest strides made in leveraging 2D MXenes for cutting-edge regenerative medicine and tissue engineering applications while shedding light on the formidable obstacles and promising future vistas awaiting exploration with these extraordinary materials.
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Exploring the revolutionary potential of MXene nanoparticles in breast Cancer therapy: A review of applications and future prospects
(Elsevier BV, 2025-04)
Ali Mohammad Amani
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Lobat Tayebi
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Ehsan Vafa
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Reza Bazargan-Lari
;
Milad Abbasi
Breast cancer is a leading cause of cancer-related deaths in women worldwide. Early detection and accurate diagnosis are crucial for successful treatment and improving patient outcomes. Nanoparticles, such as MXenes, have emerged as a promising tool for various breast cancer applications due to their unique properties. MXenes possess a high surface area and excellent biocompatibility, and can be engineered to enhance targeting ability, as well as mechanical, electrochemical, and optical properties. This review article explores the potential of MXenes in breast cancer detection and treatment, including miRNA detection, MRI-guided photothermal therapy, combined therapy, and immunotherapy. MXenes can be used for miRNA detection, which has shown promise as a biomarker for breast cancer. MXenes can also be used for MRI-guided photothermal therapy, where they can absorb light and convert it into heat to destroy cancer cells. Additionally, MXenes can be used in combination therapy with other drugs to enhance their efficacy. MXenes can also be used for immunotherapy by enhancing the immune response against cancer cells. The article also discusses the future prospects of MXenes in breast cancer research and their cytotoxicity effects. The use of MXenes in breast cancer research is a novel approach with great potential for improving patient outcomes.
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Mxenes as a versatile nanoplatform: Synthesis and emerging biomedical applications
(Elsevier BV, 2025-09-25)
Ali Mohammad Amani
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Ehsan Vafa
;
Maryam Mirzae
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Milad Abbasi
;
Ahmad Vaez
Recently, MXenes have garnered significant attention in academic research due to their remarkable structural, electrical, magnetic, optical, mechanical, and chemical properties. New advancements and emerging findings indicate that MXene, classified as a two-dimensional (2D) layered material, exhibits significantly more potential in the field of biomedicine and biotechnology compared to existing nanosystems. These applications include acting as antibacterial agents, biosensor systems, the delivery and loading of drugs, bioimaging, and therapeutic interventions. The unique characteristics of MXenes, such as their significant electrical conductivity, large surface area, low toxicity, magnetism, luminescence, and high biocompatibility, make them highly promising candidates for diagnostic, therapeutic, and theranostic applications. Surface modifications of MXenes exhibit biocompatibility and have multifunctional functions, including the ability to direct ligands towards specific spots for preferential aggregation, hence enabling their utilization in specialized applications. This paper provides an overview of the characteristics, modifications, and synthesis methods of MXene nanomaterials. The present article also delivers a comprehensive assessment of the practical uses of MXene-based nanomaterials in biomedicine, with a particular focus on biosensing, bioimaging, antibacterial effects, implants, and multifunctional therapeutic platforms. This paper also presents a discussion of the future prospects and challenges associated with the applications of MXenes in the biomedicine field.
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MXene-based materials for enhanced water quality: Advances in remediation strategies
(Elsevier BV, 2025-02-01)
Ali Mohammad Amani
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Milad Abbasi
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Atena Najdian
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Farzaneh Mohamadpour
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Seyed Reza Kasaee
Two-dimensional MXenes are promising candidates for water treatment because of their large surface area (e.g., exceeding 1000 m²/g for certain structures), high electrical conductivity (e.g., >1000 S/m), hydrophilicity, and chemical stability. Their strong sorption selectivity and effective reduction capacity, exemplified by heavy metal adsorption efficiencies exceeding 95 % in several studies, coupled with facile surface modification, make them suitable for removing diverse contaminants. Applications include the removal of heavy metals (e.g., achieving >90 % removal of Pb(II)), dye removal (e.g., demonstrating >80 % removal of methylene blue), and radioactive waste elimination. Furthermore, 3D MXene architecture exhibit enhanced performance in antibacterial activities (e.g., against bacteria), desalination rejection percentage, and photocatalytic degradation of organic contaminants. However, several challenges have remained, which necessitate further investigation into toxicity (e.g., assessing effects on aquatic organisms), scalability, and cost-effectiveness of large-scale production. This review summarizes recent advancements in 3D MXene-based functional materials for wastewater treatment and water remediation, critically analyzing their both potential and limitations.
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On the horizon of greener pathways to travel into a greener future portal: Green MXenes, environment-friendly synthesis, and their innovative applications
(Elsevier BV, 2024-01)
Ali Mohammad Amani
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Lobat Tayebi
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Ehsan Vafa
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Milad Abbasi
;
Ahmad Vaez
It has been determined that the exceptional characteristics of MXenes are of great interest in a variety of newly developed applications. MXenes, on the other hand, have a number of drawbacks, the most significant of which is that their general manufacturing in large-scale production requires the use of ecologically hazardous and poisonous compounds, as well as a solid-state reaction at high temperature, which is then followed by selective etching. In this regard, the manner in which MXenes are manufactured is critical to determining their final applications. Thus, it is very necessary to develop strategic ways to synthesize MXenes that are safer, greener, more ecologically friendly, and more sustainable in order to put them on the market at a competitive price. It is very necessary to assemble, review, and synthesize the most recent advancements in the green-related innovation of MXenes since there are a rising number of publications on green synthesis involving technological advances and non-toxic substances. Replacing traditional synthesis methods with green MXenes, physically based rapid generation of MAX phases, molten salt process for the green synthesis of MAX phases, nanoparticulate MAX phase based on the sol-gel process, HF etchant replacement with safer chemicals, electrochemical exfoliation, and nanobioagents can result in more environmentally friendly, efficient, and safer MXenes for future environmental, biomedicine, energy saving, catalysis, and sensors. Our primary focus is on the core synthetic procedure, the mechanism, and the overall benefits, with a particular emphasis on the MXene features that have been passed down from these green synthesis approaches. The growing uses green MXenes in the fields of environmental remediation, energy conversion and storage, and biomedicine are discussed in this article. In conclusion, the remaining obstacles and potential benefits of more environmentally friendly MXene production are reviewed.

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