HESAM, KAMYAB

Preferred name

HESAM, KAMYAB

Main Affiliation

Facultad de Arquitectura y Urbanismo

Now showing 1 - 10 of 56

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Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery
(Elsevier BV, 2025-07-01)
Milad Abbasi
;
Hossein Aghamollaei
;
Ahmad Vaez
;
Ali Mohammad Amani
;
HESAM, KAMYAB
The distinctive benefits and drawbacks of various drug delivery strategies to supply corneal tissue improvement for sense organs have been the attention of studies worldwide in recent decades. Static and dynamic barriers of ocular tissue prevent foreign chemicals from entering and inhibit the active absorption of therapeutic medicines. The distribution of different medications to ocular tissue is one of the most appealing and demanding tasks for investigators in pharmacology, biomaterials, and ophthalmology, and it is critical for cornea wound healing due to the controlled release rate and increased drug bioavailability. It should be mentioned that the transport of various types of medications into the different sections of the eye, particularly the cornea, is exceedingly challenging because of its distinctive structure and various barriers throughout the eye. Nanoparticles are being studied to improve medicine delivery strategies for ocular disease. Repetitive corneal drug delivery using biodegradable nanocarriers allows a medicine to remain in different parts of the cornea for extended periods of time and thus improve administration route effectiveness. In this review, we discussed eye anatomy, ocular delivery barriers, as well as the emphasis on the biodegradable nanomaterials ranging from organic nanostructures, such as nanomicelles, polymers, liposomes, niosomes, nanowafers, nanoemulsions, nanosuspensions, nanocrystals, cubosomes, olaminosomes, hybridized NPs, dendrimers, bilosomes, solid lipid NPs, nanostructured lipid carriers, and nanofiber to organic nanomaterials like silver, gold, and mesoporous silica nanoparticles. In addition, we describe the nanotechnology-based ophthalmic medications that are presently on the market or in clinical studies. Finally, drawing on current trends and therapeutic approaches, we discuss the challenges that innovative optical drug delivery systems confront and propose future research routes. We hope that this review will serve as a source of motivation and inspiration for developing innovative ophthalmic formulations.
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Nanomaterials and hydrogen production: A comprehensive Review of clean energy strategies, costs, and environmental implications
(Elsevier BV, 2025-09)
Fazil Qureshi
;
Mohammad Asif
;
Mohd Yusuf Khan
;
Abuzar Khan
;
Mohd Naved Khan
An increasing demand for energy coupled with rising pollution levels is driving the search for environmentally clean alternative energy resources to replace fossil fuels. Hydrogen has emerged as a promising clean energy carrier and raw material for various applications. However, its environmental benefits depend on sustainable production methods. The rapid development of nanomaterials (NMs) has opened new avenues for the conversion and utilization of renewable energy (RE). NMs are becoming increasingly important in addressing challenges related to hydrogen (H₂) generation. This review provides an overview of current advancements in H₂ production from biomass via thermochemical (TC) and biological (BL) processes, including associated costs, and explores the applications of nanomaterials in these methods. Research indicates that biological hydrogen (BL-H₂) production remains costly. The challenges associated with the TC conversion process are examined, along with potential strategies for improvement. Finally, the technical and economic obstacles that must be overcome before hydrogen can be widely adopted as a fuel are discussed.
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The hybrid attic ventilation technique as a sustainable strategy for thermal comfort improvement and energy saving in tropical residential buildings
(Elsevier BV, 2025-04-01)
Mahdi Moharrami
;
Aidin Nobahar Sadeghifam
;
Hamed Golzad
;
Eeydzah binti Aminudin
;
Seyedeh Sara Miryousefi Ata
Thermal comfort in hot-humid tropical climates, such as Malaysia's, is significantly affected by solar radiation, humidity, and air temperature. Solar radiation heats the roof, warming the enclosed attic space and distributing heat throughout the building's interior. In tropical regions, the attic is integral to the building, and inadequate ventilation can elevate the overall thermal load. This study investigates the impact of a hybrid attic ventilation technique designed to operate continuously over 24 h on enhancing thermal comfort and increasing energy savings. Field measurements were conducted simultaneously in two typical one-storey terrace houses: one with conventional attic conditions and the other equipped with hybrid attic ventilation. Building Information Modelling (BIM) was used to simulate and analyse energy consumption. The results demonstrated that the hybrid ventilation system improved thermal comfort by reducing indoor temperature by 1 °C and relative humidity by 7%, achieving a 10% reduction in overall building energy consumption. The results showed that this hybrid technique effectively enhances thermal comfort and energy efficiency through continuous operation, showing the benefits of both nighttime and daytime ventilation.
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Effect of Bioactive Glass on PXDDA - PXDDA-co-PLA Nanocomposite for Hard Tissue Reconstruction: Synthesis and Characterization
(Elsevier BV, 2025-05)
Ehsan Vafa
;
Lobat Tayebi
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Fatemeh Azizli
;
Somayeh Parham
;
Katayoon Rezaeeparto
Newer bone graft materials face various challenges in achieving optimal mechanical strength, bioactivity, and antibacterial action simultaneously, which can result in suboptimal regeneration outcomes and increased infection risks In the present study, we developed a novel nanocomposite of poly (xylitol- co -dodecanedioic acid) (PXDDA) and poly (lactic acid) (PLA) with 1–10 wt% incorporation of bioactive glass (BG), utilizing a a PXDDA-co-PLA compatibilizer for maintaining homogeneity. Extensive characterization techniques including, Fourier infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauere Emmette Teller (BET), Proton Nuclear Magnetic Resonance (1H NMR) and contact angle measurements, revealed that the addition of BG imparted a microporous, rough surface morphology (with a contact angle of 55–60°), ideal for cell attachment. Mechanical testing demonstrated a significant enhancement with 10 wt% BG, increasing tensile strength by approximately 120 % while reducing elongation. In vitro bioactivity tests indicated that hydroxyapatite deposition depended on BG concentration, reaching a maximum of 96.7 % surface coverage at 10 wt% BG. Antibacterial action against Staphylococcus aureus and Escherichia coli confirmed substantial inhibition (approximately 85 % decrease), with saturation occurring at 7 wt% BG. With tunable mechanical properties, enhanced biomineralization, and intrinsic antibacterial capacity, this nanocomposite overcomes the significant limitations of existing bone grafts, providing a clinically viable load-bearing alternative.
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Mxenes as a versatile nanoplatform: Synthesis and emerging biomedical applications
(Elsevier BV, 2025-09-25)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Recently, MXenes have garnered significant attention in academic research due to their remarkable structural, electrical, magnetic, optical, mechanical, and chemical properties. New advancements and emerging findings indicate that MXene, classified as a two-dimensional (2D) layered material, exhibits significantly more potential in the field of biomedicine and biotechnology compared to existing nanosystems. These applications include acting as antibacterial agents, biosensor systems, the delivery and loading of drugs, bioimaging, and therapeutic interventions. The unique characteristics of MXenes, such as their significant electrical conductivity, large surface area, low toxicity, magnetism, luminescence, and high biocompatibility, make them highly promising candidates for diagnostic, therapeutic, and theranostic applications. Surface modifications of MXenes exhibit biocompatibility and have multifunctional functions, including the ability to direct ligands towards specific spots for preferential aggregation, hence enabling their utilization in specialized applications. This paper provides an overview of the characteristics, modifications, and synthesis methods of MXene nanomaterials. The present article also delivers a comprehensive assessment of the practical uses of MXene-based nanomaterials in biomedicine, with a particular focus on biosensing, bioimaging, antibacterial effects, implants, and multifunctional therapeutic platforms. This paper also presents a discussion of the future prospects and challenges associated with the applications of MXenes in the biomedicine field.
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Nanobioremediation of heavy metals using microorganisms
(Elsevier BV, 2025-09)
HESAM, KAMYAB
;
Shreeshivadasan Chelliapan
;
Elham Khalili
;
ZULETA MEDIAVILLA, DIANA PATRICIA
;
KHORAMI, MAJID
Heavy metals (HMs) in soil are a big threat to environmental and agricultural sustainability. This review discusses the development of the nanobioremediation paradigm (an approach combining nanotechnology and microbiological processes) for the treatment of HM toxicity. Recent advances in nanoparticle (NP)-based approaches to their ability to improve microbial detoxification methods, such as adsorption, redox transformation, and enzyme activation forms of microbial detoxification are discussed. Key findings suggest that many engineered NPs (e.g., zero-valent iron, biogenic metal oxides) can enhance HM immobilization efficiencies and contour microbial performances and functions of the soil microbiome. Still, there are areas of uncertainty regarding NP-microbe-soil interactions, long-term ecotoxicological effects, and applicability at the field level that are critical to be discussed. Future research directions are advised to focus on the eco-designed NPs, optimizing microbial consortia specific to the soil, and interdisciplinary frameworks linking the laboratory methods and materials to the real-world applications.
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Hybrid Photocatalytic Porphyrin-Functionalized UiO-66/BiVO4 for Enhanced CO2 Reduction Using Photosystem II
(Wiley, 2025-09-04)
Van Duc Bui
;
Thi Huong Vu
;
Thi Phuong Anh Tran
;
Le Minh Khoa Nguyen
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HESAM, KAMYAB
Harnessing abundant solar energy for sustainable fuel production offers one of the most encouraging strategies to mitigate CO2 emissions. The discovery of novel and efficient photocatalysts to enhance photocatalytic CO2 reduction is important for converting solar energy to fuel. Porphyrin‐functionalized UiO‐66 on a BiVO4 semiconductor is introduced to convert CO2 via photoreactions. Here, the solar‐driven production of carbonaceous feedstocks is reported using a novel photocatalytic material S‐scheme UiO‐66‐TCPP‐BiVO4 heterojunction coupled with the photosystem II (PSII) in a microalgae. Coupling PSII with synthetic catalysts improves the efficiency of light‐harvesting and the CO2 reduction reaction (CO2RR). Electrochemical impedance spectroscopy, transient photocurrent response, photoluminescence lifetime, X‐ray photoelectron spectrometer, transmission electron microscope (TEM), X‐ray diffraction (XRD), and electron spin resonance measurements are conducted to determine the complex structural and electronic properties and the photocatalytic performance. In situ Fourier‐transform infrared spectra provide the CO2RR processes, revealing the mechanism by detailing intermediate formation and energy pathways.
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Synthesis and therapeutic potential of copper oxide nanoparticles from endophytic fungi: anti-cancer activities and mechanisms
(Elsevier BV, 2025-08)
Sruthi Radhakrishnan
;
Balamuralikrishnan Balasubramanian
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S. Kavibharath
;
Nivethitha Thangaraj
;
Deepak Paramasivam
Copper Oxide Nanoparticles (CuONPs) contain medicinal properties and are an essential component of the next generation due to their unique properties. CuONPs have a vital role in therapeutics, especially for cancer treatment. This study's main focus was synthesizing the CuONPs and assessing the anti-cancer activity, including the in vitro anti-angiogenesis and cytotoxicity analyses. CuONPs are synthesized using the enzymatic suspension of endophytic fungal strains FCSRL3 and FCPRS11 isolated from the Azadirachta indica grown in a minimal medium at optimum pH 7.2. About 14 different endophytic fungi confined from the neem tree, and the antagonistic and antioxidant properties were evaluated. The efficient FCSRL3 and FCPRS11 were identified as Aspergillus sydowi and Aspergillus versicolor at a molecular level. The synthesized CuONPs from two fungi were confirmed through characterization determination using SEM, EDAX, FT-IR, and XRD analyses. CuONPs revealed maximum antibacterial, antimycotic, and antioxidant activities at minimum concentration, exerting the highest bioactive properties. The anti-angiogenic activity of the CuONPs from two different fungal strains exhibited maximum inhibition of blood vessels in chick embryos, and the assessment was performed using HET-CAM. The outcomes of this research demonstrate the notable role of CuONPs in cancer remedies.
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Optimizing fish skin scaffolds for regenerative medicine: A comparative study of physical and chemical decellularization techniques
(Elsevier BV, 2026-05)
Esmat Azizipour
;
Hengameh Honarkar
;
Reza Yarahmadi
;
Ahmad Vaez
;
Mehdi Kian
Fish skin scaffolds have great potential as biocompatible materials for skin regeneration, as they contain high levels of collagen and are structurally similar to the mammalian extracellular matrix (ECM). In this study, we compared the efficiency of physical decellularization with chemical decellularization using sodium dodecyl sulphate (SDS), sodium lauryl ether sulfate (SLES), and Triton X-100 at two concentrations (0.5% and 1%) and two time intervals (6 and 12 h). The decellularization efficiency and quality of scaffolds were assessed via histological observations, glycosaminoglycan (GAG) content, MTT assay to evaluate cytocompatibility, scaffold degradation rate, and scanning electron microscopy (SEM) observations. Silicone membrane physical decellularization preserves the integrity of the ECM, retains higher levels of GAG (1.5 µg/mm³) and higher levels of fibroblast viability (p < 0.001) and demonstrates limited degradation (< 20% on day 14) compared to chemical decellularization. Chemical decellularization caused some breakdown of the ECM, particularly treatments at 1%-12h, and was able to retain lower levels of GAG (0.5–0.9 µg/mm³) while degrading more (up to 150%). SEM shows the scaffolds from the physical decellularization treatment had a clearer fibrous structure compared to the variable porosity of the chemical treatment.
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A comprehensive review on MXene nanostructures for biosensing, imaging, and therapeutic systems
(Elsevier BV, 2026-02)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Because of their exceptional electrical, mechanical, dimensional, chemical, and magnetic characteristics, MXenes have attracted an abundance of interest in scholarly study lately. According to recent developments and discoveries, MXene, a multilayered compound with a two-dimensional (2D) framework, has a lot greater promise for use in bioengineering and medical research than other nanosystems. These uses encompass medical procedures, administering medications, biosensor technologies, incorporation, antimicrobial agents, and biological imaging. MXenes are very attractive prospects for therapeutic, diagnostic, and theranostic use because of their distinctive features, which include their substantial conductivity to electricity, magnetic luminescence, wide extent of coverage, excellent biocompatibility, and low toxicological profile. Modifications to the MXene surfaces are biocompatible and serve a variety of purposes, such as directing ligands to certain locations for preferred aggregation, which makes them suitable for use in particular applications. A description of the properties, changes, and synthesis techniques of MXene nanostructures is presented in this work. The practical applications of MXene-derived nanostructures in biomedical fields are also thoroughly evaluated in this study, with an emphasis on implants, biosensing, biological imaging, antibacterial activities, and versatile therapeutic systems. The potential opportunities and difficulties related to the use of MXenes throughout the field of biological medicine are also covered in this paper.

HESAM, KAMYAB

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