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    Sustainable Groundwater Management in Water-Scarce Regions: A Spatial Machine Learning Analysis from Rajshahi, Bangladesh
    (Bilingual Publishing Group, 2025-08-12)
    Sumaya Tabassum
    ;
    Likhon Chandra Roy
    ;
    Amit Kumar Sarkar
    ;
    Yassine Ezaier
    ;
    Hader Ahmed
    Ensuring the availability and sustainable management of water (SDG 6) is particularly challenging in dry regions like Rajshahi, Bangladesh, where communities rely heavily on groundwater with limited recharge potential. Issues such as declining water levels and contamination by iron, arsenic, and chloride compromise both user satisfaction and public health. This study aimed to assess groundwater quality risks through regional mapping to guide the installation depth of new water sources. In collaboration with the Department of Public Health Engineering (DPHE), data were collected from 7,388 tube wells across nine upazilas, including well depth, geographic coordinates, and contaminant concentrations. Water quality was evaluated against World Health Organization and Bangladesh standards. Machine learning (XGBoost) and spatial analysis were applied to model contaminant levels based on location and well depth. An initial model showed poor performance, but after identifying and correcting key errors, the refined model yielded significant improvements: R² increased from 0.0345 to 0.62 for iron, from −0.0015 to 0.38 for arsenic, and from 0.12 to 0.71 for chloride. A comprehensive water quality risk map was developed by integrating these results at the upazila level. This map provides actionable insights for government agencies and NGOs to prioritize areas for water quality testing, remediation, and public awareness initiatives, contributing to more informed and sustainable water resource management in the region.
    Scopus© Citations 7
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    The hybrid attic ventilation technique as a sustainable strategy for thermal comfort improvement and energy saving in tropical residential buildings
    (Elsevier BV, 2025-04-01)
    Mahdi Moharrami
    ;
    Aidin Nobahar Sadeghifam
    ;
    Hamed Golzad
    ;
    Eeydzah binti Aminudin
    ;
    Seyedeh Sara Miryousefi Ata
    Thermal comfort in hot-humid tropical climates, such as Malaysia's, is significantly affected by solar radiation, humidity, and air temperature. Solar radiation heats the roof, warming the enclosed attic space and distributing heat throughout the building's interior. In tropical regions, the attic is integral to the building, and inadequate ventilation can elevate the overall thermal load. This study investigates the impact of a hybrid attic ventilation technique designed to operate continuously over 24 h on enhancing thermal comfort and increasing energy savings. Field measurements were conducted simultaneously in two typical one-storey terrace houses: one with conventional attic conditions and the other equipped with hybrid attic ventilation. Building Information Modelling (BIM) was used to simulate and analyse energy consumption. The results demonstrated that the hybrid ventilation system improved thermal comfort by reducing indoor temperature by 1 °C and relative humidity by 7%, achieving a 10% reduction in overall building energy consumption. The results showed that this hybrid technique effectively enhances thermal comfort and energy efficiency through continuous operation, showing the benefits of both nighttime and daytime ventilation.
    Scopus© Citations 8
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    Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery
    (Elsevier BV, 2025-07-01)
    Milad Abbasi
    ;
    Hossein Aghamollaei
    ;
    Ahmad Vaez
    ;
    Ali Mohammad Amani
    ;
    The distinctive benefits and drawbacks of various drug delivery strategies to supply corneal tissue improvement for sense organs have been the attention of studies worldwide in recent decades. Static and dynamic barriers of ocular tissue prevent foreign chemicals from entering and inhibit the active absorption of therapeutic medicines. The distribution of different medications to ocular tissue is one of the most appealing and demanding tasks for investigators in pharmacology, biomaterials, and ophthalmology, and it is critical for cornea wound healing due to the controlled release rate and increased drug bioavailability. It should be mentioned that the transport of various types of medications into the different sections of the eye, particularly the cornea, is exceedingly challenging because of its distinctive structure and various barriers throughout the eye. Nanoparticles are being studied to improve medicine delivery strategies for ocular disease. Repetitive corneal drug delivery using biodegradable nanocarriers allows a medicine to remain in different parts of the cornea for extended periods of time and thus improve administration route effectiveness. In this review, we discussed eye anatomy, ocular delivery barriers, as well as the emphasis on the biodegradable nanomaterials ranging from organic nanostructures, such as nanomicelles, polymers, liposomes, niosomes, nanowafers, nanoemulsions, nanosuspensions, nanocrystals, cubosomes, olaminosomes, hybridized NPs, dendrimers, bilosomes, solid lipid NPs, nanostructured lipid carriers, and nanofiber to organic nanomaterials like silver, gold, and mesoporous silica nanoparticles. In addition, we describe the nanotechnology-based ophthalmic medications that are presently on the market or in clinical studies. Finally, drawing on current trends and therapeutic approaches, we discuss the challenges that innovative optical drug delivery systems confront and propose future research routes. We hope that this review will serve as a source of motivation and inspiration for developing innovative ophthalmic formulations.
    Scopus© Citations 21
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    MXenes in tissue engineering and regenerative medicine: Advances, challenges, and future perspectives
    (Elsevier BV, 2025-10)
    Ali Mohammad Amani
    ;
    Lobat Tayebi
    ;
    Ehsan Vafa
    ;
    Mohammad Javad Azizli
    ;
    Milad Abbasi
    The appealing charm of two-dimensional (2D) materials has sparked a wave of innovation across diverse scientific domains, particularly in the realm of biomedical and therapeutic applications. Among these remarkable materials, MXenes stand out as transition metal nitrides and carbides endowed with extraordinary properties. Boasting low toxicity, expansive surface area, antibacterial prowess, biocompatibility, hydrophilicity, and impressive electrical conductivity, MXenes hold immense promise for a myriad of biomedical applications from bioimaging to cancer therapy and beyond. Despite their vast potential, challenges persist in ensuring controlled drug release, stability in physiological milieus, and biodegradability. By harnessing the transformative power of nanomedicine, meticulously crafted MXene ultra-thin nanosheets emerge as versatile inorganic nanosystems primed for diverse biomedical roles. Positioned as optimal candidates for regenerative medicine and tissue engineering, MXenes mark a new age of healthcare innovation. This article delves into the latest strides made in leveraging 2D MXenes for cutting-edge regenerative medicine and tissue engineering applications while shedding light on the formidable obstacles and promising future vistas awaiting exploration with these extraordinary materials.
    Scopus© Citations 9
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    Navigating green synthesized metal-based nanoparticles as anti-inflammatory agent – Comprehensive review
    (Elsevier BV, 2025-02-10)
    Sumanth Hegde
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Ridhika Paul
    ;
    M Jayalakshmi
    ;
    Aatika Nizam
    The biosynthesis of nanomaterials is a vast and expanding field of study due to their applications in a variety of fields, particularly the pharmaceutical and biomedical fields. Various synthetic routes, including physical and chemical methods, have been developed in order to generate metal nanoparticles (NPs) with definite shapes and sizes. In this review, focused on the recent advancements in the green synthetic methods for the generation of silver, zinc and copper NPs with simple and eco-friendly approaches and the potential of the biosynthesized metal and metal oxide NPs as alternative and therapeutic agent for the treatment of inflammatory diseases. Inflammation is a body's own defense mechanism that can become chronic inflammation affecting healthy cells. Owning to the size-based advantages of NPs which can mitigate in theses medical conditions and serve as anti-inflammatory drugs. The factors influencing their physicochemical properties, toxicity, biocompatibility and mode of action to formulate an effective nanomedicine in the treatment of inflammation.
    Scopus© Citations 29
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    Advances and prospects of carbon polymer dots synthesis for chemical, biological, and therapeutic applications: A comprehensive review
    (Elsevier BV, 2026-03)
    Jennifer Mariam Thomas
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Gowri Suresh
    ;
    Arun Meyyazhagan
    ;
    Haripriya Kuchi Bhotla
    Carbon dots (CDs) are a widely studied class of carbon-based nanomaterials, yet their polymeric counterpart, carbon polymer dots (CPDs), remains comparatively underexplored. CPDs are distinguished by their hybrid structure, comprising a carbon core surrounded by polymer frameworks, typically formed through partial carbonization of polymer precursors or small organic molecules. This structure preserves both polymeric and carbon dot properties, conferring superior optical features and enhanced photoluminescence quantum yield (PLQY) relative to fully carbonized CDs or uncarbonized polymer dots. CPDs are typically synthesized through bottom-up approaches, including thermal, hydrothermal, and microwave-assisted carbonization. Their structural and functional characteristics vary considerably depending on the specific synthesis conditions. Their capacity to absorb across the UV–visible–NIR spectrum enables advanced photo-responsive interactions, enhancing their potential in biomedical and biochemical systems. This review highlights CPDs’ synthesis strategies, structural mechanisms, and unique photophysical properties, while also addressing their prospective applications in biosensing, bioimaging, antibacterial platforms, and multifunctional therapeutic technologies.
    Scopus© Citations 11
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    A comprehensive review on arsenic contamination in groundwater: Sources, detection, mitigation strategies and cost analysis
    (Elsevier BV, 2025-01-15)
    Mohd Wajahat Sultan
    ;
    Fazil Qureshi
    ;
    Salman Ahmed
    ;
    ;
    Saravanan Rajendran
    While groundwater is commonly perceived as safe, the excessive presence of trace metals, particularly arsenic (As), can pose significant health hazards. This review examines the current scenario of pollutants and their mitigations focusing on As contamination in groundwater across multiple nations, with a specific emphasis on the Indian Peninsula. Arsenic pollution surpasses the WHO limit of 10 ppb in 107 countries, impacting around 230 million people worldwide, with a substantial portion in Asia, including 20 states and four union territories in India. Analysis of the correlation between the aquifer and arsenic poisoning highlights severe contamination in groundwater originating from loose sedimentary aquifer strata, particularly in recently formed mountain ranges with geological sources presumed to contribute over 90% of arsenic pollution, i.e. a big environmental challenge. A myriad of techniques, including chromatographic, electrochemical, biological, spectroscopic, and colorimetric methods among others, are available for the detection and removal of arsenic from groundwater. Removal strategies encompass a wide array of approaches such as bioremediation, adsorption, coagulation/flocculation, ion exchange, biological processes, membrane treatment, and oxidation techniques specifically tailored for affected areas. Constructed wetlands help to eliminate heavy metal impurities such as As, Zn, Cd, Cu, Ni, Fe, and Cr. Their efficiency is influenced by design and environmental factors. Nanotechnology and nanoparticles have recently been studied to remove arsenic and toxic metal ions from water. Cost-effective solutions including community-based mitigation initiatives, alongside policy and regulatory frameworks addressing arsenic contamination, are essential considerations.
    Scopus© Citations 87
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    Synthesis of Fe3O4 MIL-101-OH/Chitosan for adsorption and release of doxorubicin
    (Elsevier BV, 2025-01-01)
    Iman Najafipour
    ;
    Nafiseh Emami
    ;
    Pegah Sadeh
    ;
    Adonis Amoli
    ;
    Sareh Mosleh-Shirazi
    This study reports the synthesis and characterization of a magnetic composite metal-organic framework, The Fe3O4@MIL-101-OH/Chitosan nanocomposite was used for the first time to adsorb and release the drug doxorubicin (DOX). The nanocomposite was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The characterization results showed that the synthesized nanocomposite has a crystalline structure and good magnetic properties. Also, this nanocomposite has a high specific surface area (610.36 m2/g). In this article, the effect of pH, contact time, and drug concentration on DOX adsorption were investigated, and the results showed that at optimal conditions, pH = 8, contact time = 90 min, and drug concentration is 350 ppm, the adsorption capacity of MIL-101-OH/Chitosan and Fe3O4@MIL-101-OH/Chitosan are equal to 185 and 174.3 mg/g. The adsorption data follows pseudo-second-order kinetic and Langmuir isotherm models. The adsorption was physical and reversible. As a result, drug release was checked. The Fe3O4@MIL-101-OH/Chitosan exhibited a controlled release over the period of 84 h at pH 5 and reached 80 % of the DOX release rate after 60 h. In conclusion, the Fe3O4@MIL-101-OH/Chitosan composite has great potential as a drug delivery system as a result of its high adsorption capacity and magnetic properties. This research provides a promising approach for the development of novel drug delivery systems for cancer therapy.
    Scopus© Citations 35
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    Photocatalytic CO2 conversions on copper nanoparticles investigated by Raman spectral changes using convolutional neural networks
    (Elsevier BV, 2025-10)
    Heung Seok Lee
    ;
    Jaerin Choi
    ;
    Jin Yong Lee
    ;
    Ji Eun An
    ;
    Thi Huong Vu
    A convolutional neural network (CNN) deep learning process is employed to analyze in situ Raman scattering data for CO2 capture and its photocatalytic conversions onto copper sulfide hollow nanospheres (CuSHNSs) and copper nanocubes (CuNCs) in microalgae solution of Spirulina maxima. Raman spectra under visible light at 633 nm in a microfluidic solution provided representative vibrational marker bands of Cdouble bondO features at ∼2100 cm−1 and CH2/CH3 bending vibrations at ∼1400 cm−1 that are correlated with CO2 reduction products of carbon monoxide (C1) and multi‑carbon species such as propanol (C3), butanol (C4), respectively. Accumulated Raman spectra were trained and analyzed to estimate photocatalytic pathways using CNN algorithm. The presence of Spirulina maxima microalgae on the alteration of photocatalytic processes is studied by analyzing collective Raman spectral changes. The main observation is that strong CO peaks in Raman spectra of CO2 adsorbed by CuNCs almost disappeared after treatment with microalgae, whereas their intensities were slightly increased in case of CuSHNS. The CNN deep learning process for Raman spectra was effective to differentiate photocatalytic mechanisms of CO2 conversion onto nanoparticle surfaces.
    Scopus© Citations 4