Innovative cancer therapy: Unleashing the potential of macromolecule-loaded mesoporous bioactive glasses for precision diagnosis and treatment
Journal
International Journal of Pharmaceutics
ISSN
0378-5173
Date Issued
2024-12
Author(s)
Ali Mohammad Amani
Lobat Tayebi
Ehsan Vafa
Reza Bazargan-Lari
Milad Abbasi
Ahmad Vaez
Hesam Kamyab
Lalitha Gnanasekaran
Shreeshivadasan Chelliapan
Mohammad Javad Azizli
Abstract
Cancer continues to pose a formidable threat, claiming millions of lives annually. A beacon of hope in this battle lies in the realm of bioactive glasses, which have undergone a remarkable evolution over the past five decades.
Among these, mesoporous bioactive glasses (MBGs) emerge as a dynamic subset endowed with customizable attributes such as high surface area and porosity. While holding immense promise for cancer care, the full clinical potential of MBGs remains largely unexplored.
This review delves into the cutting-edge advancements in MBG technology, illuminating their pivotal role in cancer management – spanning from early detection to targeted therapeutic interventions like photothermal and photodynamic treatments.
Furthermore, the molecular mechanisms underpinning MBGs’ anticancer properties are elucidated, alongside an exploration of existing limitations in their application.
Through this comprehensive synthesis, the significance of MBGs in revolutionizing cancer therapy is underscored, underscoring the urgent need for continued research to unlock their full potential in reshaping the landscape of cancer care.
Among these, mesoporous bioactive glasses (MBGs) emerge as a dynamic subset endowed with customizable attributes such as high surface area and porosity. While holding immense promise for cancer care, the full clinical potential of MBGs remains largely unexplored.
This review delves into the cutting-edge advancements in MBG technology, illuminating their pivotal role in cancer management – spanning from early detection to targeted therapeutic interventions like photothermal and photodynamic treatments.
Furthermore, the molecular mechanisms underpinning MBGs’ anticancer properties are elucidated, alongside an exploration of existing limitations in their application.
Through this comprehensive synthesis, the significance of MBGs in revolutionizing cancer therapy is underscored, underscoring the urgent need for continued research to unlock their full potential in reshaping the landscape of cancer care.