The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
Journal
Allergy
ISSN
1398-9995
Date Issued
2024-02-17
Author(s)
Ioana Agache
Carlos Canelo‐Aybar
Isabella Annesi‐Maesano
Lorenzo Cecchi
Benedetta Biagioni
Fan Chung
Gennaro D'Amato
Athanasios Damialis
Stefano Del Giacco
Leticia De las Vecillas
Javier Dominguez‐Ortega
Carmen Galàn
Stefanie Gilles
Mattia Giovannini
Stephen Holgate
Mohamed Jeebhay
Kari Nadeau
Nikolaos Papadopoulos
Santiago Quirce
Joaquin Sastre
Claudia Traidl‐Hoffmann
Jolanta Walusiak‐Skorupa
Bernardo Sousa‐Pinto
Josefina Salazar
L. Yesenia Rodríguez‐Tanta
Yahveth Cantero
Yang Song
Giancarlo Alvarado‐Gamarra
Ivan Sola
Pablo Alonso‐Coello
Wendy Nieto‐Gutierrez
Marek Jutel
Cezmi A. Akdis
Abstract
Abstract
Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact).
MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new‐onset asthma and critical and important asthma‐related outcomes.
Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new‐onset wheeze (moderate certainty evidence).
Exposure to cleaning agents may be associated with a higher risk of new‐onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new‐onset asthma (very low certainty evidence).
The impact on asthma‐related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma‐related outcomes more rigorous research in the field is warranted.
Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact).
MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new‐onset asthma and critical and important asthma‐related outcomes.
Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new‐onset wheeze (moderate certainty evidence).
Exposure to cleaning agents may be associated with a higher risk of new‐onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new‐onset asthma (very low certainty evidence).
The impact on asthma‐related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma‐related outcomes more rigorous research in the field is warranted.