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Identification of genetic biomarkers to predict the response to nutritional therapy in patients with Type 2 Diabetes
Journal
Salud, Ciencia y Tecnología
ISSN
2796-9711
Date Issued
2025-01-13
Author(s)
Domenica Monserrath Robayo Poveda
Nathaly Michelle Sánchez Guarnizo
Ángel Rafael Balarezo Montaño
Carlos Fabian Argotti Zumbana
Edison Joshua Jijón Sánchez
Stephanie Marie Cruz Pierard
Oscar Isidro Sánchez Ganchozo
Abstract
Introduction: The identification of genetic biomarkers to predict the response to nutritional therapy in patients with type 2 diabetes (T2D) has become a promising area to improve the response to therapeutic interventions. In addition, biomarkers are of great help as biological determinants, to study, evaluate and determine Diabetes Mellitus 2.
Objective: To analyze the genetic biomarkers associated with the response to nutritional therapy in patients with type 2 diabetes, in order to contribute to the development of personalized strategies that optimize metabolic control and improve the effectiveness of nutritional treatment.
Methodology: Systematic review based on PRISMA. 15 studies published between 2018-2023 in databases such as PubMed, Scopus, Scielo, etc. were included. The inclusion criteria were articles on genetic biomarkers, original, systematic review, case studies. Publications prior to 2017, theses and duplicate articles, articles without free access were excluded.
Results: The findings highlight the importance of polygenic markers and epigenetic factors, such as DNA methylation, in predicting therapeutic outcomes. Furthermore, the influence of dietary patterns on biomarker expression emphasizes the potential of personalized nutritional strategies in the management of type 2 diabetes.
Conclusion: Despite advances in biomarker research, further studies are needed, particularly in Latin American populations, to develop effective interventions tailored to genetic profiles. This study underscores the importance of integrating genetic and environmental factors to improve clinical outcomes in the treatment of type 2 diabetes.
Objective: To analyze the genetic biomarkers associated with the response to nutritional therapy in patients with type 2 diabetes, in order to contribute to the development of personalized strategies that optimize metabolic control and improve the effectiveness of nutritional treatment.
Methodology: Systematic review based on PRISMA. 15 studies published between 2018-2023 in databases such as PubMed, Scopus, Scielo, etc. were included. The inclusion criteria were articles on genetic biomarkers, original, systematic review, case studies. Publications prior to 2017, theses and duplicate articles, articles without free access were excluded.
Results: The findings highlight the importance of polygenic markers and epigenetic factors, such as DNA methylation, in predicting therapeutic outcomes. Furthermore, the influence of dietary patterns on biomarker expression emphasizes the potential of personalized nutritional strategies in the management of type 2 diabetes.
Conclusion: Despite advances in biomarker research, further studies are needed, particularly in Latin American populations, to develop effective interventions tailored to genetic profiles. This study underscores the importance of integrating genetic and environmental factors to improve clinical outcomes in the treatment of type 2 diabetes.