Oesophageal adenocarcinoma, obesity, and cancer: the role of nutrition in prevention and management
Journal
Food and Agricultural Immunology
ISSN
0954-0105
Date Issued
2025-05-29
Author(s)
Emilia Jiménez Flores
Martín Campuzano Donoso
Angelo Michele Carella
Luigi Coppola
Marco Marchetti
Raynier Zambrano Villacres
Gerardo Sarno
Abstract
Oesophageal adenocarcinoma (EAC) is increasingly associated with obesity, metabolic dysfunction, and genetic predispositions.
This review explores how nutritional factors interact with these risk elements, emphasizing the potential of dietary strategies in EAC prevention and management. Diets such as the Mediterranean and plant-based patterns may reduce inflammation, oxidative stress, and metabolic imbalance, thereby modulating cancer risk. Nutrient-rich foods–particularly omega-3 fatty acids, cruciferous vegetables, and dietary fibre–offer additional protective effects.
Personalized nutrition, tailored to individual genetic and metabolic profiles, is emerging as a promising tool in cancer prevention.
Moreover, weight management strategies like caloric restriction and intermittent fasting may contribute to risk reduction. Integrating these approaches into clinical and public health practices could play a critical role in mitigating the underlying drivers of EAC. Further research is needed to strengthen dietary guidelines and advance precision nutrition for high-risk populations.
This review explores how nutritional factors interact with these risk elements, emphasizing the potential of dietary strategies in EAC prevention and management. Diets such as the Mediterranean and plant-based patterns may reduce inflammation, oxidative stress, and metabolic imbalance, thereby modulating cancer risk. Nutrient-rich foods–particularly omega-3 fatty acids, cruciferous vegetables, and dietary fibre–offer additional protective effects.
Personalized nutrition, tailored to individual genetic and metabolic profiles, is emerging as a promising tool in cancer prevention.
Moreover, weight management strategies like caloric restriction and intermittent fasting may contribute to risk reduction. Integrating these approaches into clinical and public health practices could play a critical role in mitigating the underlying drivers of EAC. Further research is needed to strengthen dietary guidelines and advance precision nutrition for high-risk populations.