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Author: search.filters.author.Shreeshivadasan ChelliapanSubject: search.filters.subject.Antifungal

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    Exploring the functionality of MXenes as promising versatile antimicrobial agents and their novel applications
    (Elsevier BV, 2024-12)
    Ali Mohammad Amani
    ;
    Ali Rahbar
    ;
    Ehsan Vafa
    ;
    Lobat Tayebi
    ;
    Milad Abbasi
    Given the increasing drug resistance exhibited by viruses, fungi, and bacteria, there is an urgent demand for the creation and utilization of novel structures that possess exceptional efficacy. MXenes have demonstrated potent bactericidal activity, effectively suppressing the growth of gram- negative and gram- positive bacterial strains. Their mode of antimicrobial action primarily involves disrupting the bacterial cell membrane. Additionally, MXenes exhibit antifungal properties, holding promise for applications in combating fungal infections. Emerging studies suggest that certain MXenes can also possess antiviral properties, impacting both enveloped and non-enveloped viruses. Researchers are exploring their use in wound healing, where they can prevent infections and accelerate the healing process. Furthermore, MXenes can be integrated into coatings, composites, and surfaces, finding applications in medical devices, textiles, and food packaging for antimicrobial purposes. The potential for MXenes to be employed in photothermal and photodynamic therapy adds another layer to their multifaceted antimicrobial capabilities. When activated by light, MXenes can target and eliminate cancer cells or pathogens. Research in this domain is progressing, with the prospect of novel materials and strategies to combat bacterial, fungal, and viral infections. This article discussed recent progress in the field of antibacterial, anti-fungal, and antiviral properties of MXenes and MXene-derived materials. Furthermore, their biocompatibility and toxicity issues, as well as the challenges and future opportunities of MXenes in the field of antimicrobial applications, are discussed. Overall, MXenes hold considerable promise for addressing the pressing global concern of antimicrobial resistance and opening new avenues for advanced medical technologies.
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    Bromelain-loaded silver nanoparticles: Formulation, characterization and biological activity
    (Elsevier BV, 2024-03)
    Farshid Gheisari
    ;
    Seyed Reza Kasaee
    ;
    Pardis Mohamadian
    ;
    Shreeshivadasan Chelliapan
    ;
    Razieh Gholizadeh
    Bromelain (BL), a type of proteolytic enzymes from Ananas comosus (pineapple), has a variety of therapeutic potentials; nevertheless, its low bioavailability has restricted the clinical applications. The main aim of the current research was to develop a green synthesized Ag-BL nanoparticles via a cost-effective route to improve the physicochemical and antimicrobial characteristics as a novel agent for medical applications. In the present study, Bromelain was loaded on the silver nanoparticle surface via covalent bonds through green synthesis method. The physicochemical properties of Ag-BL nanoparticles characterized by following a detailed analysis over scanning electron microscopy, zeta potential, ultraviolet–visible absorption spectroscopy, transmission electron microscopy, fourier transform infrared spectroscopy, and X-ray diffraction studies. The antifungal and antibacterial activity were investigated by the Clinical and Laboratory Standards Institute methods and the results were compared with Ag NPs and plain bromelain. The cytotoxicity of Ag-BL nanoparticles was investigated by MTT assay. The TEM and XRD techniques revealed the successful biosynthesis of Ag-BL nanoparticles in spherical shape with the mean size of 7 to 24 nm and FTIR analysis pattern proved the attachments of bromelain and Ag nanoparticles in the fabricated nanostructure. The negative zeta value of the Ag-BL nanoparticles (−50 to –32 mV) indicates their high stability in the suspension. The Ag-BL nanoparticles demonstrated significant antimicrobial activity against various types of fungi and bacteria strains with a MIC range of 4–32 and 4–64 μg/mL, respectively. The MTT assay analysis determined the acceptable cell safety of Ag-BL nanoparticles. Generally, the results confirmed that Ag-BL nanoparticles could develop a new insight to produce antimicrobial products for biomedical applications.