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Author: search.filters.author.REYTOR GONZÁLEZ CLAUDIA

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    Obesity and endometrial cancer: biological mechanisms, nutritional strategies, and clinical perspectives
    (Informa UK Limited, 2025-04-12)
    Simancas Racines Daniel
    ;
    Campuzano Donoso Martín
    ;
    Román-galeano Náthaly Mercedes
    ;
    Zambrano Villacres Raynier
    ;
    Pasqualina Memoli
    Obesity is a major modifiable risk factor for endometrial cancer, significantly increasing incidence and worsening clinical outcomes. The underlying biological mechanisms include chronic inflammation, insulin resistance, hormonal dysregulation, and microbiome alterations, all of which contribute to tumour development and progression. Nutritional strategies such as plant-based and Mediterranean diets, caloric restriction, and micronutrient-rich foods show promise in reducing cancer risk through improved metabolic health and hormonal balance. However, clinical challenges persist, including surgical complications, altered chemotherapy efficacy, and poorer long-term survival in obese patients. Personalised nutrition and multidisciplinary care integrating oncology, nutrition, and metabolic expertise are essential for improving treatment outcomes. Despite promising evidence, knowledge gaps remain in understanding microbiome interactions and the long-term efficacy of dietary interventions. Addressing these challenges through research and clinical innovation is crucial to mitigating the burden of obesity-related endometrial cancer and enhancing patient care.
    Scopus© Citations 19
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    Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies
    (Informa UK Limited, 2025-05-06)
    REYTOR GONZÁLEZ CLAUDIA
    ;
    SIMANCAS RACINES DANIEL
    ;
    Campuzano Donoso Martín
    ;
    Castano Jimenez Janeth C.
    ;
    Román-galeano Náthaly Mercedes
    Metabolic dysfunction-associated steatotic liver disease is a growing global health issue linked to obesity, insulin resistance, and metabolic syndrome. Diet plays a key role in its progression and management. This narrative review highlights evidence-based nutritional strategies, including the Mediterranean diet, low-carbohydrate and ketogenic diets, and high-fiber intake, which improve insulin sensitivity, reduce hepatic fat, and lower inflammation. Nutritional deficiencies, such as low vitamin D, choline, and omega-3 levels, exacerbate metabolic dysfunction-associated steatotic liver disease, emphasizing the need for targeted supplementation. Emerging approaches, including gut microbiota modulation, precision nutrition, and nutraceuticals like resveratrol and curcumin, offer promising therapeutic potential. A multidisciplinary approach integrating dietary and lifestyle modifications is essential for effective metabolic dysfunction-associated steatotic liver disease management.
    Scopus© Citations 11
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    Effectiveness and Safety of Preoperative Nutritional Interventions on Surgical Outcomes in Patients Undergoing Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis
    (MDPI AG, 2025-04-30)
    Simancas Racines Daniel
    ;
    REYTOR GONZÁLEZ CLAUDIA
    ;
    Juan Marcos Parise-Vasco
    ;
    Jaime Angamarca-Iguago
    ;
    Eloisa Garcia-Velasquez
    Background: Preoperative nutritional interventions, including low-calorie diets (LCDs) and very low-calorie diets (VLCDs), are commonly implemented in metabolic and bariatric surgery. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of preoperative dietary interventions in patients undergoing bariatric surgery, with primary outcomes including perioperative complications, operative time, and length of hospital stay. Methods: A systematic review and meta-analysis were conducted, including studies that compared LCD and VLCD with regular diets in adults undergoing bariatric surgery. The primary outcomes assessed were perioperative complications, operative time, and length of hospital stay. Random- and fixed effects models were used for quantitative synthesis. Risk of bias was evaluated using the Cochrane Risk of Bias tool and ROBINS-I, while the certainty of evidence was assessed using the GRADE approach. Results: Eight trials comprising 1197 patients were included in the meta-analysis. VLCDs were associated with a significant reduction in perioperative complications (OR 0.59; 95% CI: 0.37–0.94; p = 0.03), whereas LCDs showed no significant effect on complications (OR 1.64; 95% CI: 0.71–3.78; p = 0.25). No significant reduction in operative time was observed (MD −2.64 min; 95% CI: −6.01 to 0.73; p = 0.12). Hospital stay was slightly reduced (MD −0.17 days; p = 0.0001), though the clinical significance remains uncertain. The certainty of evidence was low, primarily due to the risk of bias and small sample sizes. Conclusions: VLCDs may lower the risk of perioperative complications, while LCDs do not appear to provide this benefit. However, the evidence is limited by methodological heterogeneity and low certainty. Further high-quality studies are needed to establish optimal preoperative nutritional protocols.
    Scopus© Citations 12