CRIS :: Universidad UTE

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Dielectrophoresis-based microfluidics for detection and separation of circulating tumor cells
(Elsevier BV, 2025-06-01)
Najafipour, Iman
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Pegah Sadeh
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Amani Ali Mohammad
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Hesam Kamyab
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Chelliapan, Shreeshivadasan
Circulating tumor cells (CTCs) represent a critical focus in cancer research due to their potential to enable early detection, monitor disease progression, and facilitate personalized therapies. However, existing isolation techniques often face significant limitations, including low specificity, reduced recovery rates, and the inability to preserve cellular viability for downstream applications such as genetic profiling and drug testing. This review addresses a key knowledge gap in the development of efficient, label-free, and scalable technologies for CTC isolation, emphasizing the role of dielectrophoresis (DEP)-based microfluidic systems. DEP leverages the intrinsic dielectric properties of cells to enable selective and non-invasive separation, eliminating the need for surface markers and ensuring high cell integrity. The study highlights the integration of nanomaterials, such as gold nanoparticles and graphene oxide nanosheets, as a novel approach to overcome existing challenges in DEP-based platforms. These nanomaterials improve the specificity and sensitivity of CTC capture by increasing surface area and biocompatibility. Key advancements discussed include the optimization of electrode designs, tuning of electric field parameters, and innovative system configurations that enhance recovery efficiency and separation purity. The review also compares various DEP configurations, such as electrode-based, insulator-based, and contactless systems, evaluating their unique advantages and suitability for different applications. In addition to reviewing current advancements, the paper outlines future directions for the field, emphasizing the need for large-scale clinical validation to establish DEP-based systems as reliable diagnostic tools. This review provides a comprehensive framework for advancing DEP-based microfluidic platforms, offering a transformative approach for early cancer detection, personalized medicine, and the broader application of innovative diagnostic technologies in clinical settings.
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Biochar as a carrier for plant growth-promoting bacteria in phytoremediation of pesticides
(Elsevier BV, 2025-05-01)
HESAM, KAMYAB
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Chelliapan, Shreeshivadasan
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Elham Khalili
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Rezania, Shahabaldin
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Balasubramanian, Balamuralikrishnan
This review examines the role of biochar as a carrier for plant growth-promoting bacteria (PGPB) in the phytoremediation process of pesticides. It begins by exploring the properties and performance of biochar, including its production processes and physical and chemical characteristics. The review then discusses the roles and mechanisms of PGPB, such as nitrogen fixation, phosphate solubilization, and phytohormone production, emphasizing how these bacteria can enhance plant growth and tolerance to environmental stresses while aiding in pesticide degradation. The suitability of biochar as a carrier for PGPB is highlighted due to its porous structure, surface chemistry, and ability to create microbial habitats. The interactions between biochar, PGPB, and plants that can enhance phytoremediation efficiency are examined. The review additionally identifies the related challenges and limitations, suggesting areas for further research to develop practical applications. This review aims to provide a comprehensive overview of the potential of biochar as a carrier for PGPB in improving phytoremediation outcomes, explicitly addressing the lack of prior reviews on this topic and highlighting broader implications for sustainable remediation.
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A state of the art review on geotechnical reinforcement with end life tires
(2024)
Shariati, M.
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Afrazi, M.
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Kamyab, H.
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Rouhanifar, S.
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Toghroli, E.
This study provides a comprehensive exploration of the utilization of scrap tires in geotechnical engineering, focusing on their applications, mechanical behavior, environmental impact, and potential challenges. The utilization of waste tires in engineering applications is of paramount importance, offering a sustainable solution to the escalating challenge of waste tire management. The accumulation of discarded tires poses significant environmental and economic concerns globally, with traditional disposal methods often leading to environmental degradation, fire hazards, and increased land use. By harnessing the inherent properties of scrap tires, such as their durability and energy-absorbing characteristics, geotechnical engineering presents a promising path for repurposing these materials. This review examines how integrating scrap tires into geotechnical projects, such as retaining walls, slopes, and drainage systems, can offer sustainable alternatives while addressing environmental concerns. The paper extensively analyzes the mechanical behavior of sand-rubber mixtures through laboratory investigations. Factors including rubber proportions, aspect ratios, and interaction mechanisms are dissected to understand their influence on shear strength, deformation behavior, and modulus properties. These insights pave the way for optimizing the performance of sand-rubber mixtures in engineering applications. Additionally, the article delves into modeling approaches that simulate the intricate behavior of these mixtures, facilitating better design and analysis. The economic feasibility of incorporating scrap tires is investigated, emphasizing the cost-effectiveness achieved through reduced material costs and enhanced infrastructure durability. The environmental benefits of diverting rubber waste from landfills are discussed, highlighting the alignment with sustainability goals and regulations. Despite the advantages, engineering challenges associated with rubber particles’ behavior are acknowledged, and potential solutions are explored. Through a comprehensive synthesis of research findings and practical implications, this review aims to provide a deep understanding of the potential of scrap tires in geotechnical engineering. It concludes by advocating for further research and innovation to harness the full potential of scrap tires, ultimately contributing to a more sustainable and resilient built environment.

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