CRIS

Permanent URI for this communityhttps://cris.ute.edu.ec/handle/123456789/1

Browse

Settings

Author: search.filters.author.Balamuralikrishnan BalasubramanianSubject: search.filters.subject.Sustainability

Search Results

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Navigating green synthesized metal-based nanoparticles as anti-inflammatory agent – Comprehensive review
    (Elsevier BV, 2025-02-10)
    Sumanth Hegde
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Ridhika Paul
    ;
    M Jayalakshmi
    ;
    Aatika Nizam
    The biosynthesis of nanomaterials is a vast and expanding field of study due to their applications in a variety of fields, particularly the pharmaceutical and biomedical fields. Various synthetic routes, including physical and chemical methods, have been developed in order to generate metal nanoparticles (NPs) with definite shapes and sizes. In this review, focused on the recent advancements in the green synthetic methods for the generation of silver, zinc and copper NPs with simple and eco-friendly approaches and the potential of the biosynthesized metal and metal oxide NPs as alternative and therapeutic agent for the treatment of inflammatory diseases. Inflammation is a body's own defense mechanism that can become chronic inflammation affecting healthy cells. Owning to the size-based advantages of NPs which can mitigate in theses medical conditions and serve as anti-inflammatory drugs. The factors influencing their physicochemical properties, toxicity, biocompatibility and mode of action to formulate an effective nanomedicine in the treatment of inflammation.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    A review on ethanol tolerance mechanisms in yeast: Current knowledge in biotechnological applications and future directions
    (Elsevier BV, 2024-03)
    Gandasi Ravikumar Sahana
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Kadanthottu Sebastian Joseph
    ;
    Manikantan Pappuswamy
    ;
    Wen-Chao Liu
    Saccharomyces cerevisiae is one of the prominent strains in the brewing and bioethanol industries and has been used for many industrial purposes for ages. Though the organism is an outstanding ethanol producer, the major limiting factor is the stress the organism undergoes during fermentation. One of the significant stresses is the ethanol stress, created by ethanol accumulation in the medium. The ethanol starts to interact with the yeast cell membrane; further, as ethanol concentration increases, it affects a lot of cell organelles. Thereby, cellular activities get disrupted, causing cell death and hence reducing ethanol production. The organism has developed many strategies to overcome this stress by activating the stress response pathway, which regulates many genes involved in modifying the cell membrane cell wall, renaturation of proteins, and altering the metabolism. However, with higher ethanol concentrations, the yeast cells will be unable to tolerate, leading to cell death. Hence, to minimize cell death at higher ethanol concentrations, there is a need to understand the effect of ethanol and its response by the organism; this helps improve the ethanol tolerance of the organism and, thereby, ethanol production. Although many research works are carried out to understand the vital aspect of the tolerance and are reported, very few review papers cover all these points. Hence, this review is designed to include information on all the elements of ethanol tolerance, i.e., ethanol tolerance of different strains of S. cerevisiae, the effect of ethanol on the yeast cells, the mechanism used to tolerate the ethanol, and various techniques developed to improve the ethanol tolerance of the yeast cells.