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Author: search.filters.author.Balamuralikrishnan BalasubramanianSubject: search.filters.subject.Nanoparticles

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    Item type:Publication,
    Fungal biopolymer-based nanoparticles for wound healing: Mechanisms, applications, and future perspectives
    (Elsevier BV, 2025-12-01)
    Kaakarlu Shivakumar Vinanthi Rajalakshmi
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Hemanth Hinnakki
    ;
    Arun Meyyazhagan
    ;
    Wen-Chao Liu
    Fungal derived biopolymers have emerged as a promising alternative to the existing synthetic materials and have gained heightened interest in wound healing platforms due to their unique properties, such as durability, biodegradability, biocompatibility, low-toxicity, non-immunogenicity, and analogy to the native extracellular matrix. Major fungal biopolymers such as chitin, chitosan, β-glucan, mannan, and pullulans offer several biomedical and clinical advantages in wound healing to remodel the injured tissue, making them suitable for accelerating the various phases of wound healing. These biopolymers not only support cell proliferation, angiogenesis, and tissue remodelling but also serve as effective carriers for controlled drug delivery, enhancing the efficacy of therapeutic agents to accelerate the cellular responses at the wound site. The review also outlines the biological processes involved in various phases of wound healing to provide insight into future explorations in developing optimized wound dressings that ensure maximal reduction of inflammation and allow skin to remodulate. Fungal-mediated nanoparticles and hybrid nanocomposites have further improved the functional performance of wound dressings by providing increased mechanical stability, biocompatibility, and targeted bioactivity. Collectively, these findings highlight the significant role of fungal biopolymer-based nanoparticles as a novel, sustainable, and effective regime for advanced wound management.
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    Navigating green synthesized metal-based nanoparticles as anti-inflammatory agent – Comprehensive review
    (Elsevier BV, 2025-02-10)
    Sumanth Hegde
    ;
    Balamuralikrishnan Balasubramanian
    ;
    Ridhika Paul
    ;
    M Jayalakshmi
    ;
    Aatika Nizam
    The biosynthesis of nanomaterials is a vast and expanding field of study due to their applications in a variety of fields, particularly the pharmaceutical and biomedical fields. Various synthetic routes, including physical and chemical methods, have been developed in order to generate metal nanoparticles (NPs) with definite shapes and sizes. In this review, focused on the recent advancements in the green synthetic methods for the generation of silver, zinc and copper NPs with simple and eco-friendly approaches and the potential of the biosynthesized metal and metal oxide NPs as alternative and therapeutic agent for the treatment of inflammatory diseases. Inflammation is a body's own defense mechanism that can become chronic inflammation affecting healthy cells. Owning to the size-based advantages of NPs which can mitigate in theses medical conditions and serve as anti-inflammatory drugs. The factors influencing their physicochemical properties, toxicity, biocompatibility and mode of action to formulate an effective nanomedicine in the treatment of inflammation.