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A comprehensive review on MXene nanostructures for biosensing, imaging, and therapeutic systems
(Elsevier BV, 2026-02)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Because of their exceptional electrical, mechanical, dimensional, chemical, and magnetic characteristics, MXenes have attracted an abundance of interest in scholarly study lately. According to recent developments and discoveries, MXene, a multilayered compound with a two-dimensional (2D) framework, has a lot greater promise for use in bioengineering and medical research than other nanosystems. These uses encompass medical procedures, administering medications, biosensor technologies, incorporation, antimicrobial agents, and biological imaging. MXenes are very attractive prospects for therapeutic, diagnostic, and theranostic use because of their distinctive features, which include their substantial conductivity to electricity, magnetic luminescence, wide extent of coverage, excellent biocompatibility, and low toxicological profile. Modifications to the MXene surfaces are biocompatible and serve a variety of purposes, such as directing ligands to certain locations for preferred aggregation, which makes them suitable for use in particular applications. A description of the properties, changes, and synthesis techniques of MXene nanostructures is presented in this work. The practical applications of MXene-derived nanostructures in biomedical fields are also thoroughly evaluated in this study, with an emphasis on implants, biosensing, biological imaging, antibacterial activities, and versatile therapeutic systems. The potential opportunities and difficulties related to the use of MXenes throughout the field of biological medicine are also covered in this paper.
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Mxenes as a versatile nanoplatform: Synthesis and emerging biomedical applications
(Elsevier BV, 2025-09-25)
Ali Mohammad Amani
;
Ehsan Vafa
;
Maryam Mirzae
;
Milad Abbasi
;
Ahmad Vaez
Recently, MXenes have garnered significant attention in academic research due to their remarkable structural, electrical, magnetic, optical, mechanical, and chemical properties. New advancements and emerging findings indicate that MXene, classified as a two-dimensional (2D) layered material, exhibits significantly more potential in the field of biomedicine and biotechnology compared to existing nanosystems. These applications include acting as antibacterial agents, biosensor systems, the delivery and loading of drugs, bioimaging, and therapeutic interventions. The unique characteristics of MXenes, such as their significant electrical conductivity, large surface area, low toxicity, magnetism, luminescence, and high biocompatibility, make them highly promising candidates for diagnostic, therapeutic, and theranostic applications. Surface modifications of MXenes exhibit biocompatibility and have multifunctional functions, including the ability to direct ligands towards specific spots for preferential aggregation, hence enabling their utilization in specialized applications. This paper provides an overview of the characteristics, modifications, and synthesis methods of MXene nanomaterials. The present article also delivers a comprehensive assessment of the practical uses of MXene-based nanomaterials in biomedicine, with a particular focus on biosensing, bioimaging, antibacterial effects, implants, and multifunctional therapeutic platforms. This paper also presents a discussion of the future prospects and challenges associated with the applications of MXenes in the biomedicine field.
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Multifunctional MXenes nanocomposite platforms for biosensing and wearable sensor technologies
(Springer Science and Business Media LLC, 2025-02-01)
Ali Mohammad Amani
;
Hesam Kamyab
;
Ehsan Vafa
;
Alireza Jahanbin
;
Milad Abbasi
MXenes are nanostructures with unique characteristics, such as hydrophilicity, large surface area, strong metallic conductivity, strong ion transport capabilities, biocompatibility, minimal diffusion barrier, and easy functionalization, which make these compounds suitable for bioanalytical applications. These materials are formed of transition metallic nitrides, carbides, or carbonitrides. Owing to their unique properties, MXenes have gained interest in various fields, including sustainable energy generation, fuel cells, supercapacitors, electronics, and catalysis. The composition and layered structure have made MXenes particularly appealing to biosensing applications. They can be used in electrochemical biosensors because of their high conductivity and multilayered architecture, which ensure the retention of activity in immobilized biomolecules. This review highlights the application of MXenes in electrochemical and optical biosensors, identifying future requirements and potential in this sector, particularly in the development of wearable sensors and platforms with integrated biomolecule detection.

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