HESAM, KAMYABKAMYABHESAMElham KhaliliTayebeh KhademiAli YuzirMohammad Mahdi TaheriSaravanan RajendranPEÑAHERRERA PAZMIÑO, ANA BELÉNANA BELÉNPEÑAHERRERA PAZMIÑO2026-02-092026-02-092026-03https://doi.org/10.1016/j.mtsust.2025.101287Green synthesis of nanoparticles (NPs) has garnered a considerable amount of attention lately due to its low production expenses, simplicity of manufacturing, safety, and environmental friendliness. It is a dependable method for creating a variety of nanostructures from fungal, plant, and bacterial extracts as well as hybrid materials, including metal salts. A viable and sustainable substitute for traditional synthesis methods is the green synthesis of NPs. According to recent research, NPs have very promising antiviral and antimicrobial capabilities. This article highlights the progress made in the green method for manufacturing NPs utilizing natural substances, including fruit juices, plant extracts, and other pertinent sources. A thorough understanding of these NPs' anticancer, antiviral, and antimicrobial abilities was presented. Numerous opportunities are presented by these NPs to combat potentially fatal viral and other antimicrobial diseases. This review provides readers with a grasp of the latest data and a variety of tactics for designing and developing advanced green nanomaterials using a more environmentally friendly approach. A summary is provided of the present difficulties, critical analysis, and prospects for the green synthesis of NPs as well as the potential for their innovative and successful investigation for biomedical applications.enAntimicrobialBiomedicineCancer therapyGreen synthesisNanoparticlestext::journal::journal article