Domenica Monserrath Robayo PovedaNathaly Michelle Sánchez GuarnizoÁngel Rafael Balarezo MontañoCarlos Fabian Argotti ZumbanaEdison Joshua Jijón SánchezJIMENEZ DURAN, DORIS JEANNETHDORIS JEANNETHJIMENEZ DURANLARREA PAREDES, MARIA DE LOURDESMARIA DE LOURDESLARREA PAREDESCRUZ PIERARD, JONATHAN LUIS GHISLAINJONATHAN LUIS GHISLAINCRUZ PIERARDStephanie Marie Cruz PierardOscar Isidro Sánchez Ganchozo2025-07-212025-07-212025-01-1310.56294/saludcyt20251290Introduction: The identification of genetic biomarkers to predict the response to nutritional therapy in patients with type 2 diabetes (T2D) has become a promising area to improve the response to therapeutic interventions. In addition, biomarkers are of great help as biological determinants, to study, evaluate and determine Diabetes Mellitus 2. Objective: To analyze the genetic biomarkers associated with the response to nutritional therapy in patients with type 2 diabetes, in order to contribute to the development of personalized strategies that optimize metabolic control and improve the effectiveness of nutritional treatment. Methodology: Systematic review based on PRISMA. 15 studies published between 2018-2023 in databases such as PubMed, Scopus, Scielo, etc. were included. The inclusion criteria were articles on genetic biomarkers, original, systematic review, case studies. Publications prior to 2017, theses and duplicate articles, articles without free access were excluded. Results: The findings highlight the importance of polygenic markers and epigenetic factors, such as DNA methylation, in predicting therapeutic outcomes. Furthermore, the influence of dietary patterns on biomarker expression emphasizes the potential of personalized nutritional strategies in the management of type 2 diabetes. Conclusion: Despite advances in biomarker research, further studies are needed, particularly in Latin American populations, to develop effective interventions tailored to genetic profiles. This study underscores the importance of integrating genetic and environmental factors to improve clinical outcomes in the treatment of type 2 diabetes.enBiomarkerNutritional TherapyType 2 Diabetesjournal-article