Ali Mohammad AmaniEhsan VafaMaryam MirzaeMilad AbbasiAhmad VaezAtena NajdianAlireza JahanbinSeyed Reza KasaeiSareh Mosleh-ShiraziHESAM, KAMYABKAMYABHESAMTayebeh KhademiShreeshivadasan ChelliapanSaravanan Rajendran2026-02-092026-02-092026-02https://doi.org/10.1016/j.sbsr.2025.100912https://cris.ute.edu.ec/handle/123456789/1898Because of their exceptional electrical, mechanical, dimensional, chemical, and magnetic characteristics, MXenes have attracted an abundance of interest in scholarly study lately. According to recent developments and discoveries, MXene, a multilayered compound with a two-dimensional (2D) framework, has a lot greater promise for use in bioengineering and medical research than other nanosystems. These uses encompass medical procedures, administering medications, biosensor technologies, incorporation, antimicrobial agents, and biological imaging. MXenes are very attractive prospects for therapeutic, diagnostic, and theranostic use because of their distinctive features, which include their substantial conductivity to electricity, magnetic luminescence, wide extent of coverage, excellent biocompatibility, and low toxicological profile. Modifications to the MXene surfaces are biocompatible and serve a variety of purposes, such as directing ligands to certain locations for preferred aggregation, which makes them suitable for use in particular applications. A description of the properties, changes, and synthesis techniques of MXene nanostructures is presented in this work. The practical applications of MXene-derived nanostructures in biomedical fields are also thoroughly evaluated in this study, with an emphasis on implants, biosensing, biological imaging, antibacterial activities, and versatile therapeutic systems. The potential opportunities and difficulties related to the use of MXenes throughout the field of biological medicine are also covered in this paper.enBiomedicineBiosafetyFunctional groupsMXeneNanostructuresSynthesisjournal-article