Marco Faytong-HaroGenesis Camacho-LeonRobert Araujo-ContrerasStephanie GallegosHans MautongKarla Robles-VelascoRomina DominguezAndrea Mendez ColmenaresRicardo X. Noriega EspinozaFernando PeñaKeila Carrera-MejiasGuillermo Leon-SamaniegoREYTOR GONZÁLEZ, CLAUDIA MARÍACLAUDIA MARÍAREYTOR GONZÁLEZNUÑEZ VASQUEZ, CRISTINA ELIZABETHCRISTINA ELIZABETHNUÑEZ VASQUEZIvan Cherrez-OjedaSIMANCAS RACINES, DANIEL ALEJANDRODANIEL ALEJANDROSIMANCAS RACINES2025-10-132025-10-132025-10-01https://doi.org/10.1186/s12939-025-02612-1Background: Depression significantly impacts health systems worldwide, particularly in Latin America, where cultural stigmatization and misconceptions about mental health deter individuals from seeking help. Healthcare professionals’ attitudes toward depression may affect its prevention, diagnosis and treatment. Objective: To categorize Latin American healthcare professionals’ attitudes towards diagnosis and management of depression in subgroups using the Spanish-validated Revised Depression Attitude Questionnaire (SR-DAQ). Methods: A cross-sectional study surveyed 2,409 professionals using SR-DAQ from 2019 to 2022. Latent class analysis and multinomial logistic regression were used to identify attitude classes and explore demographic influences. Results: Among our sample, four attitude classes were identified: Depression Skeptics (21%), Depression Cautious (33%), Depression Neutrals (18%), and Depression Advocates (28%). Gender and medical subspecialty significantly influenced class membership, with females and mental health specialists more likely to be part of the Advocates. Conclusion: The study reveals varied attitudes towards depression among Latin American healthcare professionals, suggesting the need for tailored public health strategies to enhance effective depression care and management.enAttitudesDepressionHealthcareLatent class analysisSR-DAQtext::journal::journal article