REYTOR GONZÁLEZ, CLAUDIA MARÍACLAUDIA MARÍAREYTOR GONZÁLEZSIMANCAS RACINES, DANIEL ALEJANDRODANIEL ALEJANDROSIMANCAS RACINESEmilia Jiménez FloresMartín Campuzano DonosoAngelo Michele CarellaLuigi CoppolaMarco MarchettiRaynier Zambrano VillacresGerardo Sarno2025-07-182025-07-182025-05-29https://doi.org/10.1080/09540105.2025.2510951Oesophageal adenocarcinoma (EAC) is increasingly associated with obesity, metabolic dysfunction, and genetic predispositions. This review explores how nutritional factors interact with these risk elements, emphasizing the potential of dietary strategies in EAC prevention and management. Diets such as the Mediterranean and plant-based patterns may reduce inflammation, oxidative stress, and metabolic imbalance, thereby modulating cancer risk. Nutrient-rich foods–particularly omega-3 fatty acids, cruciferous vegetables, and dietary fibre–offer additional protective effects. Personalized nutrition, tailored to individual genetic and metabolic profiles, is emerging as a promising tool in cancer prevention. Moreover, weight management strategies like caloric restriction and intermittent fasting may contribute to risk reduction. Integrating these approaches into clinical and public health practices could play a critical role in mitigating the underlying drivers of EAC. Further research is needed to strengthen dietary guidelines and advance precision nutrition for high-risk populations.encancerhealthcarenutritionnutritional strategiesobesityOesophageal adenocarcinomajournal-article